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Table 5 Relationship between log Leptin and Fetal ultrasound markers

From: Maternal cardiometabolic markers are associated with fetal growth: a secondary exploratory analysis of the LIMIT randomised trial

Ultrasound Measure

Unadjusted Estimate (95% CI)

Unadjust p value

Adjusted Estimate (95% CI)

Adjusted p value

EFW

 

0.815

 

0.785*

 - 28 Weeks

−40.68 (−79.26, −2.09)

0.039

−41.08 (− 83.65, 1.49)

0.059

 - 36 Weeks

−32.84 (−95.88, 30.20)

0.307

−31.83 (−95.48, 31.83)

0.327

SSFM

 

0.925

 

0.999*

 - 28 Weeks

0.01 (− 0.17, 0.20)

0.880

0.14 (− 0.06, 0.34)

0.167

 - 36 Weeks

0.03 (− 0.24, 0.30)

0.833

0.14 (− 0.13, 0.41)

0.303

AFM

 

0.988

 

0.912*

 - 28 Weeks

− 0.02 (− 0.22, 0.17)

0.814

0.03 (− 0.19, 0.24)

0.802

 - 36 Weeks

− 0.02 (− 0.33, 0.28)

0.894

0.01 (− 0.30, 0.32)

0.960

MTFM

 

0.561

 

0.563

 - 28 Weeks

− 0.25 (− 0.51, 0.00)

0.053

− 0.37 (− 0.67, − 0.07)

0.015*

 - 36 Weeks

−0.08 (− 0.65, 0.49)

0.778

− 0.20 (− 0.76, 0.36)

0.488

MTLM

 

0.231

 

0.191*

 - 28 Weeks

0.07 (−0.13, 0.27)

0.496

0.00 (−0.24, 0.24)

0.995

 - 36 Weeks

−0.16 (− 0.50, 0.19)

0.373

− 0.25 (− 0.60, 0.10)

0.167

AC

 

0.705

 

0.631*

 - 28 Weeks

−0.25 (− 0.52, 0.02)

0.065

− 0.26 (− 0.54, 0.02)

0.067

 - 36 Weeks

− 0.19 (− 0.48, 0.11)

0.221

− 0.18 (− 0.48, 0.13)

0.259

BPD

 

0.400

 

0.420*

 - 28 Weeks

− 0.02 (− 0.09, 0.05)

0.605

− 0.01 (− 0.08, 0.06)

0.735

 - 36 Weeks

0.02 (− 0.04, 0.08)

0.614

0.02 (− 0.04, 0.08)

0.525

HC

 

0.343

 

0.380*

 - 28 Weeks

− 0.12 (− 0.35, 0.11)

0.303

− 0.10 (− 0.34, 0.14)

0.425

 - 36 Weeks

0.02 (− 0.19, 0.23)

0.878

0.03 (− 0.19, 0.25)

0.791

FL

 

0.392

 

0.369*

 - 28 Weeks

−0.03 (− 0.09, 0.02)

0.244

− 0.02 (− 0.08, 0.04)

0.442

 - 36 Weeks

− 0.00 (− 0.05, 0.05)

0.880

0.01 (− 0.04, 0.06)

0.729

EFW z score

 

0.900

 

0.901*

 - 28 Weeks

−0.05 (− 0.18, 0.09)

0.476

− 0.06 (− 0.20, 0.09)

0.432

 - 36 Weeks

−0.04 (− 0.17, 0.10)

0.567

− 0.05 (− 0.19, 0.09)

0.498

AC z score

 

0.865

 

0.832*

 - 28 Weeks

−0.04 (− 0.18, 0.11)

0.603

− 0.05 (− 0.21, 0.10)

0.513

 - 36 Weeks

−0.02 (− 0.17, 0.12)

0.749

−0.03 (− 0.18, 0.12)

0.668

BPD z score

 

0.909

 

0.810*

 - 28 Weeks

0.11 (− 0.12, 0.35)

0.344

0.12 (−0.13, 0.36)

0.340

 - 36 Weeks

0.10 (−0.07, 0.27)

0.239

0.09 (−0.09, 0.27)

0.336

HC z score

 

0.970

 

0.850*

 - 28 Weeks

0.04 (−0.11, 0.19)

0.584

0.04 (−0.12, 0.21)

0.607

 - 36 Weeks

0.04 (−0.11, 0.18)

0.600

0.03 (−0.13, 0.18)

0.736

FL z score

 

0.515

 

0.506*

 - 28 Weeks

0.00 (−0.16, 0.17)

0.954

0.03 (−0.14, 0.20)

0.736

 - 36 Weeks

0.07 (−0.09, 0.23)

0.407

0.10 (−0.07, 0.27)

0.268

  1. Results are expressed as the expected difference (ratio) and 95% confidence intervals
  2. Adjusted analyses including BMI category (< 30 vs ≥30), study centre, parity (0 vs ≥1), age at consent, smoking status and SEIFA IRSD quintile
  3. * p value for test of time-by-log Leptin interaction to test whether the association between fetal ultrasound measure and log Leptin are different at 36 weeks to the association at 28 weeks
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BMC Endocrine Disorders

ISSN: 1472-6823

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