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Table 2 The characteristics of uterus parameters according to breast Tanner stages, M (P25, P75)

From: The pubertal development mode of Chinese girls with turner syndrome undergoing hormone replacement therapy

Stage

N

Duration since HRT (yr)

Estradiol valerate (mg/d)

Uterine volume (ml)

Uterine length (cm)

Uterine width (cm)

Uterine cross (cm)

Uterus endometrium (cm)

 

Z, P

 

Z, P

 

Z, P

 

Z, P

B1

TS

71

–

–

0.56 (0.35, 1.24)

−0.17, 0.089

1.80 (1.20, 2.40)

−0.792, 0.429

0.60 (0.50, 1.00)

−0.174, 0.081

1.00 (0.80, 1.10)

−2.86, 0.004

–

control

18

–

–

0.89 (0.59, 1.50)

1.65 (1.56, 1.85)

0.80 (0.68, 1.10)

1.25 (1.00, 1.40)

–

B2

TS

33

0.33 (0.25, 0.42)

0.50 (0.28, 0.50)

2.86 (1.93, 6.37)*

−3.105,0.002

2.60 (2.20, 2.90)*

−4.04,<0.0001

1.25 (1.10, 1.50)*

−2.17, 0.03

1.80 (1.50, 1.70)

−2.27, 0.023

2.00 (1.00, 2.75)

control

34

–

–

1.60 (0.95, 2.53)

1.90 (1.68, 2.20)

1.05 (0.90, 1.30)

1.55 (1.20, 1.90)

 

B3

TS

56

0.83 (0.5, 1.23)

0.70 (0.50, 1.00)

5.22 (2.42, 11.00)*

−2.509, 0.012

2.85 (2.32, 3.68)*

−3.539,<0.0001

1.70 (1.33, 2.10)***

−1.802, 0.072

2.0 (1.50, 2.67)

−1.622, 0.105

2.00 (0.75, 3.00)

control

48

–

–

2.77 (1.76, 4.26)

2.35 (2.00, 2.60)

1.35 (1.10, 1.80)

1.75 (1.40, 2.10)

 

B4

TS

37

2.00 (0.75, 3.00)

1.25 (0.86, 2.00)

7.68 (4.82, 14.10)**

−1.999, 0.046

3.40 (3.00, 4.00)**

−0.959, 0.338

1.80 (1.60, 2.58)*

−2.214, 0.027

2.60 (1.90, 3.00)**

−1.868, 0.062

3.00 (2.00, 6.90)

control

11

–

–

13.79 (9.27, 23.06)

3.70 (3.10, 4.20)

2.70 (2.20, 2.90)

3.10 (2.30, 3.90)

 

B5

TS

17

3.58 (1.96, 4.71)

1.50 (1.00, 2.00)

11.69 (6.84, 13.65)

−2.124, 0.034

3.40 (3.05, 4.10)

−2.025, 0.043

2.10 (1.95, 2.63)

−1.869, 0.066

2.90 (2.15, 3.28)

−0.984, − 0.33

3.00 (1.00, 6.00)

control

8

–

–

17.86 (14.44, 20.71)

4.40 (3.72, 4.80)

2.50 (2,33, 2.68)

3.05 (2.63, 3.80)

 
  1. Legend: We analyzed the uterine parameters and endometrium thickness according to breast Tanner stage and compared them with the previous stage. The uterine volume, length, width and cross-section increased significantly in every breast stage compared with the stage before except that in stage B5 (B2–3: Z = −2.031, −2.425, − 2.663; P = 0.042, 0.015, 0.008, 0.473; B3–4: Z = − 2.273, − 2.367, − 1.771, − 2.227; P = 0.023, 0.018, 0.077, 0.026; B4–5: Z = − 1.368, − 1.073, − 1.889, − 1.45; P = 0.171, 0.283, 0.059, 0.147; respectively). Compared with the normally developing girls, the girls with TS showed that uterine volume grew more quickly in stage B2 and B3 but more slowly in B4 and B5
  2. Footnote: *: the data for the present stage compared with the last stage; P <0.05, **: P <0.01, ***P <0.001
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BMC Endocrine Disorders

ISSN: 1472-6823

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