Relationship between inflammatory markers and mild cognitive impairment in Chinese patients with type 2 diabetes: a case-control study

Table 4 Odds ratios of MCI for inflammatory markers

Variables	Tertile	Controls/ Case	Model 1		Model 2		Model 3
Variables	Tertile	Controls/ Case	OR(95%CI)	P value	OR(95%CI)	P value	OR(95%CI)	P value
TNF-α	< 26.33 pg/ml	26/16	1.00	–	1.00	–	1.00	–
	26.33–33.83 pg/ml	20/22	1.38 (0.73–2.62)	0.332	1.46 (0.75–2.83)	0.133	1.48 (0.76–2.89)	0.250
	≥33.83 pg/ml	17/25	1.56 (0.83–2.93)	0.163	1.47 (0.77–2.80)	0.238	1.41 (0.74–2.69)	0.296
IL-6	< 16.91 pg/ml	31/11	1.00	–	1.00	–	1.00	–
	16.91–25.35 pg/ml	24/18	1.64 (0.77–3.47)	0.198	1.90 (0.88–4.12)	0.105	1.96 (0.90–4.26)	0.091
	≥25.35 pg/ml	8/34	3.09 (1.57–6.10)	0.001	3.15 (1.58–6.28)	0.001	3.12 (1.56–6.24)	0.001
hs-CRP	< 0.63 mg/L	30/12	1.00	–	1.00	–	1.00	–
	0.63–1.67 mg/L	18/24	2.00 (1.00–4.00)	0.050	1.87 (0.92–3.79)	0.083	1.79 (0.88–3.66)	0.108
	≥1.67 mg/L	15/27	2.25 (1.14–4.44)	0.019	2.14 (1.05–4.35)	0.035	2.02 (0.98–4.14)	0.055

Model 1: Crude model
Model 2: Adjusted for diabetes related factors including duration of diabetes (per year), HbA1c (< 7.0%/≥7.0%), anti-diabetic medications (only oral hypoglycemic agents /only insulin/insulin plus oral hypoglycemic agents), diabetic retinopathy (yes/no) and diabetic nephropathy (yes/no), and common cardiovascular diseases risk factors including smoking status (yes/no), body mass index (< 24.0 kg/m²/24.0–28.0 kg/m²/≥28.0 kg/m²), hypertension (yes/no), LDL-C (< 2.6 mmol/L/≥2.6 mmol/L)
Model 3: Model 2 plus serum folate (< 7.0 μg/L/≥7.0 μg/L)
IL-6 Interleukin-6, TNF-α Tumor necrosis factor-α, hs-CRP High-sensitivity C-reactive protein

ISSN: 1472-6823