The impact of cancer on diabetes outcomes

Arreskov, Anne Beiter; Olsen, Maria Å.; Pouplier, Sandra Sinius; Siersma, Volkert; Andersen, Christen L.; Friis, Søren; de Fine Olivarius, Niels

doi:10.1186/s12902-019-0377-0

BMC Endocrine Disorders

Table 4 Mortality and other outcomes for patients with and without cancer in patients receiving structured or routine care during 19 years of follow up

From: The impact of cancer on diabetes outcomes

	No. of patients with outcome during 19 years of follow up (n (%))		Incidence rate (events per 1000 patient years, 95% CI)		Hazard ratio^a (95% CI) for structured care versus routine care^b	P value^c	Inter-ac-tion P value^d
	Structured personal care	Routine care	Structured personal care	Routine care		P value^c	Inter-ac-tion P value^d
All-cause mortality
Cancer	147 (84.5)	101 (86.3)	220.1 (185.9–258.7)	237.0 (193.1–288.1)	0.97 (0.67–1.41)	0.89	0.65
No cancer	375 (63.9)	343 (68.2)	45.8 (41.3–50.7)	51.2 (45.9–56.9)	0.89 (0.76–1.03)	0.12	0.65
Diabetes-related deaths
Cancer	58 (33.5)	38 (32.5)	86.8 (65.9–112.3)	89.2 (63.1–122.5)	1.01 (0.63–1.63)	0.96	0.75
No cancer	269 (45.9)	240 (47.9)	32.8 (29.0–37.0)	35.8 (31.4–40.6)	0.93 (0.77–1.13)	0.46	0.75
Any diabetes-related endpoint
Cancer	79 (53.4)	58 (61.1)	339.8 (269.0–423.6)	612.5 (465.0–792.2)	0.75 (0.49–1.16)	0.19	0.81
No cancer	331 (70.6)	314 (75.3)	58.9 (52.8–65.7)	71.1 (63.5–79.4)	0.80 (0.68–0.93)	0.005	0.81
Myocardial infarction
Cancer	42 (25.2)	34 (31.2)	77.0 (55.5–104.1)	114.9 (79.5–160.7)	0.94 (0.53–1.69)	0.84	0.50
No cancer	177 (33.5)	176 (38.8)	23.7 (20.3–27.5)	29.5 (25.3–34.2)	0.76 (0.62–0.94)	0.011	0.50
Stroke
Cancer	23 (13.9)	19 (17.6)	43.4 (27.4–65.1)	53.9 (32.4–84.3)	0.65 (0.30–1.41)	0.27	0.38
No cancer	133 (23.7)	127 (26.3)	17.8 (14.9–21.1)	21.0 (17.5–25.0)	0.94 (0.74–1.11)	0.60	0.38
Peripheral vascular disease
Cancer	4 (2.3)	4 (3.5)	6.1 (1.6–15.8)	9.8 (2.6–25.4)	0.85 (0.49–1.48)	0.99	0.88
No cancer	31 (5.3)	30 (6.0)	3.8 (2.6–5.5)	4.6 (3.1–6.5)	0.99 (0.16–6.13)	0.57	0.88
Microvascular disease
Cancer	20 (11.6)	13 (11.1)	33.4 (20.4–51.7)	33.3 (17.7–56.2)	1.35 (0.51–3.57)	0.37	0.39
No cancer	78 (13.3)	70 (13.9)	9.9 (7.8–12.4)	11.0 (8.6–13.9)	0.85 (0.60–1.21)	0.55	0.39

^aThe hazard ratio (HR) is calculated in a Cox proportional hazard regression model where the first cancer diagnosis is a time-varying covariate. The corresponding 95% CI and P values are determined using a sandwich estimator for the variance to account for clustering of patients within practices
^bAdjusted for age, sex and clustering, as well as for the following variables at diagnosis: live alone, basic school education, body mass index, hypertension, diagnostic fasting plasma glucose, total cholesterol, sedentary physical activity, and current smoking
^cTests the effect of randomization within patient groups with and without cancer. ^dTests whether the effect of randomization is different between patient groups with and without cancer
The effectiveness of the intervention

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