HNF1A gene p.I27L is associated with early-onset, maturity-onset diabetes of the young-like diabetes in Turkey

Table 3 Genotype analysis of HNF1A gene SNPs

	Controls, n	Diabetes, n	OR (95% CI)	P
*I27L* rs1169288 (%)
*Co-dominant Wild type GG	105	146
Heterozygous GT	120	233	1.02 (0.57–1.78)	0.984
Homozygous TT	38	110	1.71 (1.25–3.46)	0.024
Dominant (GT + TT/GG)	158 vs 105	343 vs 146	1.68 (1. 21-2.13)	0.035
Recessive (TT/GT + GG)	38 vs 225	110 vs 379	1.56 (1. 14-2.57)	0.048
*S487 N* rs2464196 (%)
*Co-dominant Wild type CC	102	188
Heterozygous CT	121	210	0.58 (0.35–1.39)	0.471
Homozygous TT	40	91	1.25 (0.57–2.75)	0.638
Dominant (CT + TT/CC)	161 vs 102	301 vs 188	1.01 (0.74–1.38)	0.938
Recessive (TT/CT + CC)	40 vs 223	91 vs 398	1.27 (0.84–1.91)	0.241
*A98V* rs1800574 (%)
*Co-dominant Wild type CC	208	411
Heterozygous CT	52	64	1.26 (0.48–3.29)	0.676
Homozygous TT	3	14	1.35 (0.95–3.54)	0.027
Dominant model (CT + TT/CC)	55 vs 208	78 vs 411	0.71 (0.48–1.05)	0.089
Recessive model (TT/CT + CC)	3 vs 260	14 vs 475	2.55 (0.72–8.97)	0.130

*Co-dominat model was compared wild type, homozygous variant and heterozygous variant were compared
DM Diabetes mellitus, OR odds ratio, CI confidence interval
Data are shown as mean ± standard deviation (means ± SD) and percentage (%)
Bold represents the significant p-values
Categorical variables were analyzed with Chi-square test or Fisher’s exact test, where appropriate
Multiple logistic regression analysis and Fisher’s exact test were tested using models: dominant (major allele homozygotes vs heterozygotes + minor allele homozygotes), recessive (major allele homozygotes + heterozygotes vs minor allele homozygotes) and codominant (major allele homozygotes vs heterozygote and minor allele homozygotes vs major allele homozygotes)

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