Table 5 Definitive pathology examination and immunohistochemistry
From: Calcitonin negative Medullary Thyroid Carcinoma: a challenging diagnosis or a medical dilemma?
Authors | Cell morphological characteristics | Neuroendocrine tumor structure | Amyloid substance | Lymph node metastasis | Thyroid capsular invasion | Vascular tumor thrombus |
|---|---|---|---|---|---|---|
Sobol | Ovoid-to-spindle-shaped in groups divided by fibrous septum | Neurosecretory granules | Focal | NA | NA | NA |
Schmid 1 | Polygonal and spindle cells | NA | NA | NA | Negative | Negative |
Schmid 2 | Polygonal and spindle cells | NA | NA | NA | Negative | Negative |
Schmid 3 | Polygonal and spindle cells | NA | NA | NA | Positive | Positive |
Schmid 4 | Polygonal and spindle cells | NA | NA | NA | Positive | Positive |
Redding | Nets of fairly uniform cells | NA | NA | NA | Negative | NA |
Bockhorn | Polyhedral and spindle cells | Positive | NA | NA | Negative | NA |
Sand | NA | NA | NA | Positive | Positive | Positive |
Dora | Spindle-shaped celss | NA | Positive | Positive | Positive | Positive |
Wang | NA | NA | Negative | Positive | Positive | Positive |
Giovanella | Elongated cells | NA | NA | NA | NA | NA |
Alapat | Spindle-round-polygonal cells | NA | NA | Positive | Positive | Positive |
Chernyavsky | Fairly uniform round and polygonal cells | Positive | NA | Negative | Negative | Negative |
Nakazawa | “Zellballen” pattern | NA | NA | Negative | Negative | Negative |
Frank-Raue 1 | NA | NA | NA | NA | NA | NA |
Frank-Raue 2 | NA | NA | NA | NA | NA | NA |
Frank-Raue 3 | NA | NA | NA | NA | NA | NA |
Frank-Raue 4 | NA | NA | NA | NA | NA | NA |
Frank-Raue 5 | NA | NA | NA | NA | NA | NA |
Frank-Raue 6 | NA | NA | NA | NA | NA | NA |
Frank-Raue 7 | NA | NA | NA | NA | NA | NA |
Ismi | Atypical cells | Positive | NA | NA | NA | NA |
Brutsaert | NA | NA | NA | Negative | Positive | Negative |
Kim | NA | Positive | NA | Negative | Negative | Negative |
Kasajima | Polygonal-spindle-shaped cells | Positive | NA | Negative | Negative | Negative |
Samà 1 | Small-spindle cells | Positive | Positive | NA | NA | NA |
Samà 2 | NA | NA | NA | NA | NA | NA |
Samà 3 | NA | NA | NA | NA | NA | NA |
Samà 4 | NA | NA | NA | NA | NA | NA |
Parmer | Spindle-round cells | NA | Negative | NA | NA | NA |
Zhou | Polygonal cells in 17 cases Spindle cells in 2 cases | Positive in 16 cases Negative in 3 cases | Positive in 11 cases Negative in 8 cases | Positive in 3 cases Negative in 16 cases | Positive in 8 cases Negative in 11 cases | Positive in 1 case Negative in 18 cases |