Table 1 Main characteristic of 19 eligible studies in this meta-analysis
From: Metabolic syndrome and liver-related events: a systematic review and meta-analysis
Study authors, | Country | Type of study | Study population | Age(years) | Male:Female | N-O-Scale | RR,95%CI, and p | Follow-up period | Definition of Metabolic risk factors | Adjustment |
|---|---|---|---|---|---|---|---|---|---|---|
Inoue et al.,2008 [9] | Japan | Cohort (prospective cohort) | 27,724 total Japanese men and women (114 HCC cases) | Men:56.5 years, Women:55.5 years | 9548:18,176 | 8 | M-1.73,1.03–2.91,P=NA F-1.18,0.55–2.51,P=NA | 9–11 years | AHA | Age, sex, study area, smoking status, weekly ethanol intake |
Huo et al.,2009 [10] | China | Cohort (prospective cohort) | 1713 HCC cases(907 HCC-related died) | 65.4 years | 1313:400 | 9 | Total-1.2,1.02–1.42,P = 0.03 | 18 ± 16 months | WHO | Age, sex |
Stepanova et al.,2010 [11] | Europe and America | Case-control (retrospective cohort) | 2061 liver disease (331 died) 13,004 controls(177 died) | Case:41.1 years, Controls:44.4 years | Case:192:139 Controls:5943:7061 | 8 | Total-12.08,1.1–132.2,P = 0.042 | 12–18 years | WHO | Age, sex, smoking status |
Borena et al.,2011 [12] | Europe | Cohort (prospective cohort) | 578,700 people from Norway, Austria and Sweden(266 HCC cases) | Men:43.9 years, Women:44.1 years | 289,866:288,834 | 8 | Total-1.35,1.12–1.63,P=NA | Men for 12.8 years, Women for 11.3 years | WHO | Age, sex, smoking status |
Calori et al.,2011 [13] | Italy | Cohort (prospective cohort) | 2011 total Italians (34 liver-specific died) | 57 years | 885:1126 | 8 | Total-2.643,1.172–5.957, P < 0.0191 | 15 years | WHO | Age, sex,smoking status, alcohol intake |
Lai et al.,2011 [14] | China | Cohort (retrospective cohort) | 19,349 total Chinese (224 HCC cases) | 55.5 years | 10,792:8557 | 7 | Total-1.73,1.47–2.03, P=NA | 3–8 years | ICD | Age, sex |
Osaki et al.,2011 [15] | Japan | Cohort (prospective cohort | 23,625 Japanese men and women(129 HCC cases) | 58.6 years | 8239:15,386 | 7 | M-1.89,1.11–3.22, F-3.67,1.78–7.57, P=NA | 9.1 years | NCEP-ATP III | Age, sex,smoking status, heavy drinking |
Shau et al.,2012 [16] | China | Cohort (prospective cohort | 931 HCC cases who received surgical resection(321 liver-specific died) | 57.7 years | 679:252 | 9 | Total-1.7,1.33–2.18, P < 0.001 | 5–6 years | NCEP-ATP III | Age,sex,tumor stage |
Chen et al.,2013 [6] | China | Cohort (prospective cohort | 56,231 total Chinese men and women(262 HCC cases) | 60.9 years | 17,440:38,896 | 6 | Total-0.6,0.43–0.85, P = 0.004 | 5–7 years | AHA | Age, sex, weight, liver function |
Chiang et al.,2014 [17] | China | Cohort (prospective cohort | 50,080 Chinese men and women (235 HCC-related deaths) | M:54.2 years, F:53.7 years | 23,484:26,596 | 9 | M-2.82,1.81–4.38, P < 0.0001 F-5.60,3.26–9.64, P < 0.0001 | 10 years | WHO | Age,sex,smoking status,alcohol intake |
Calzadillabertot et al.,2016 [18] | Cuba | Cohort (prospective cohort | 250 compensated HCV-related cirrhosis(28 death and 55 decompensated) | 60 years | 96:154 | 8 | Died-2.2,1.04–4.6, P = 0.04 Decompensated- 1.9,1.05–3.3, P = 0.03 | 22–80 months | WHO | Age,sex,alcohol intake |
Cheng et al.,2016 [1] | China | Cohort (prospective cohort | 1466 CHB patients(93 hepatic events) | 46 years | 939:527 | 8 | Total-1.0,0.6–1.8, P = 0.939 | 88 ± 20 months | NCEP-ATP III | Age, sex, weight, weekly ethanol intake, liver function |
Hayashi et al.,2016 [19] | Japan | Cohort (prospective cohort | 474 Japanese non-cirrhotic patients with chronic hepatitis (21HCC cases) | 58 years | 230:244 | 9 | Total-12.8,2.81–93.0, P = 0.0006 | 8 years | HOMA | Age,sex |
Kim et al.,2016 [20] | Korea | Cohort (prospective cohort | 1696 chronic HBV infected patients (24 HCC cases) | 50 years | 964:732 | 9 | Total-3.25,1.13–9.31, P = 0.028 | 1.0–10.5 years | NCEP-ATP III | Age,sex |
Seulki Ko et al.,2016 [21] | Korea | Cohort (prospective cohort | 99,565 Koreas men and women(588 HCC cases) | Above 20 years | 61,758:37,807 | 8 | M-0.93,0.75–1.16, P=NA F-1.18,0.78–1.77, P=NA | 10.4 years | WHO | Age,sex,smoking status,alcohol intake |
Sultanik et al.,2016 [22] | France | Cohort (prospective cohort | 341 HCV patients with cirrhosis(136 HCC cases,ESLD cases,HCC and ESLD cases) | 56 years | 225:116 | 9 | Total-1.5,1.05–2.15, P = 0.03 | 8.75 years | WHO | Age,sex,alcohol intake |
Nderitu et al., 2017 [23] | Sweden | Cohort (prospective cohort | 509,436 participants (2775 cirrhosis cases,766HCC cases,158 cirrhosis and HCC cases) | 44 years | 272,167:237,269 | 9 | Cirrhosis-1.74,1.49–2.02, HCC-2.35,1.80–3.06, LREs-2.62,1.50–4.57, P=NA | 13.6 years | WHO | Age,sex |
Simon et al.,2017 [24] | USA | Cohort (prospective cohort | 171,110 Americans men and women (112 HCC cases) | 64.1 years | 50,284:120,826 | 9 | Total-4.59,2.98–7.07, P < 0.0001 | 32 years | National Diabetes Date Group | Age,sex,race,smoking status,alcohol intake |
Yu et al.,2017 [25] | China | Cohort (prospective cohort | 1690HBV carriers (158HCC cases,126 liver-related died) | 48.4 years | All men | 7 | HCC-2.32,1.18–4.54, P=NA LREs-8.57,1.18–62.15, P=NA | 19 years | Asian and Chinese Criteria | Age,smoking status,alcohol intake |