Comparison of Five TSH-Receptor Antibody Assays in Graves’ disease: results from an observational pilot study

BMC Endocrine Disorders

Table 2 Baseline characteristics of the non-GD patients

Numbers (%)	Hashimoto’s Thyroiditis	Thyroiditis	Toxic nodular goiter	Other^a	P-value^§
Sex	16 (12.2%)	9 (6.9%)	13 (9.9%)	10 (7.6%)
Female	16 (100.0%)	8 (89%)	12 (92%)	6 (60.0%)	0.23
Male	0 (0.0%)	1 (1%)	1 (8.0%)	4 (40.0%)
Age (years), mean ± SD	52 ± 13	51 ± 15	68 ± 16	53 ± 22	0.04
BMI (kg/m²), mean ± SD	25 ± 3.7	25 ± 3.2	24 ± 3.3	23 ± 3.7	0.68
IMMULITE TSI (Cut-off 0.55 U/L), median (IQR)	0.05 (0.05, 0.09)	0.05 (0.05, 0.2)	0.05 (0.05, 0.05)	0.05 (0.05, 0.05)	0.20
BRAHMS TRAK (Cut-off 1.8 U/L), median (IQR)	0.2 (0.2, 0.2)	0.2 (0.2, 0.2)	0.2 (0.2, 0.62)	0.2 (0.2, 0.2)	0.88
EliA anti-TSH-R (Cut-off 2.9 U/L), median (IQR)	1.4 (1.4, 1.4)	1.4 (.9, 1.9)	1.4 (.9, 1.4)	1.4 (1.2, 1.7)	0.60
RSR TRAb Fast (Cut-off 1.0 U/L), median (IQR)	0.9 (0.9, 0.9)	0.9 (0.9, 1.1)	0.9 (0.9, 0.9)	0.9 (0.9, 1.1)	0.09
RSR-bioassay STIMULATION (Cut-off 150%), median (IQR)	94 (85, 119)	98 (91, 131)	87 (86, 92)	98 (93, 182)	0.12

Abbreviation: CD celiac disease, GIT gastrointestinal tract, IBD inflammatory bowel disease, IQR interquartile range, pM pmol/L, SD standard deviation, T1DM type 1 diabetes mellitus
^aOther includes: amiodarone induced hyperthyroidism, euthyroid sick syndrome, postpartum thyroiditis, silent thyroiditis, euthyroid goiter, follicular and papillary carcinoma, functional TSH suppression after i.v. contrast agent
^§categorical and binary variables were compared by Pearson’s chi-squared test, continuous, non-normally distributed variables were compared by Wilcoxon rank-sum test; P-values not adjusted to multiple testing

ISSN: 1472-6823