Development and validation of a predictive model for incident type 2 diabetes in middle-aged Mexican adults: the metabolic syndrome cohort

Table 3 Assessment of anthropometric, demographic and biochemical risk factors for incident diabetes obtained through unadjusted Cox-proportional hazard regression analyses in Mexican population according to predefined cut-off values

Parameter	β	HR	95%CI	P-value
Age ≥ 40 years	0.537	1.711	1.345–2.175	<0.001
Family history of T2D	0.287	1.332	1.069–1.660	0.011
Waist circumference (IDF)	0.918	2.505	1.677–3.744	<0.001
Waist circumference (ATP-III)	0.660	1.934	1.539–2.430	<0.001
Overweight 25–29.99 kg/m²	0.453	1.572	1.068–2.316	0.022
Obesity (≥30 kg/m2)	0.902	2.464	1.685–3.605	<0.001
High Waist-hip ratio^a	0.542	1.720	1.346–2.198	<0.001
Waist-height index > 0.5	0.983	2.673	1.499–4.767	<0.001
Blood pressure > 140/90 mmHg	0.672	1.958	1.566–2.447	<0.001
Fasting glucose 100–110 mg/dL	1.470	4.347	3.378–5.594	<0.001
Fasting glucose 111–125 mg/dL	2.353	10.512	7.792–14.182	<0.001
Fasting insulin ≥15uUI/L	0.634	1.886	1.501–2.368	<0.001
HOMA2-IR > 2.5	0.871	2.389	1.877–3.042	<0.001
Fasting triglycerides > 150 mg/dL	0.824	2.280	1.767–2.943	<0.001
Total colesterol > 200 mg/dL	0.391	1.478	1.174–1.861	0.001
Low HDL-C	−0.225	0.798	0.636–1.003	0.053
Non-HDL-C > 130 mg/dL	0.599	1.820	1.325–2.500	<0.001
Apolipoprotein B (>90th percentile)	0.415	1.515	1.205–1.903	<0.001
CPR ≥2.3	0.470	1.600	1.278–2.003	<0.001

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