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Table 3 Predictors of Lower extremity amputations

From: Incidence and determinants of diabetes-related lower limb amputations in Ghana, 2010–2015- a retrospective cohort study

Predictor Unadjusted HR (95% CI) P-Value Adjusted HR (95% CI) P-Value
Gender
 Male 5.28 (3.11–8.96) < 0.001 3.50 (2.88–5.23) < 0.001
 Female 1    
Age at presentation
 10 years age increase 1.40 (1.19–1.65) < 0.001 1.11 (1.06–1.22) < 0.001
Duration of diabetes
 5 year increase 2.40 (0.92–3.14) < 0.07  
Type of DM
 Type 1 1   1  
 Type 2 6.20 (3.13–9.43) < 0.001 8.21 (2.58–10.7) < 0.001
 Specific type 0.50 (0.32–1.21) 0.32   
Body mass index
 Each 5 kg/m2 increase 5.3 (3.11–8.96) < 0.001 3.2 (2.51–7.25) < 0.001
Glycemic control
 A percentage increase in HbA1c 1.23 (1.08–1.42) 0.003 1.11 (1.05–1.25) 0.03
Dyslipidaemia
 Present 0.84 (0.51–1.36) 0.47
 Absent 1    
Complications
Hypertension 1.51 (1.02–1.71) < 0.001 1.14 (1.12–3.21) < 0.001
Nephropathy 1.6 (0.8–2.3) 0.07
A 10/mL/min/1.73 m 2 drop in eGFR
Peripheral sensory neuropathy 7.28 (6.38–9.21) < 0.001 6.56 (6.21–8.52) < 0.001
Peripheral Vascular Disease 9.76 (5.67–12.21) < 0.001 7.73 (4.39–9.53) < 0.001