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Table 1 Information of selected studies

From: Assisted reproductive techniques with congenital hypogonadotropic hypogonadism patients: a systematic review and meta-analysis

Author, year

No.pts

Age mean/SD (year)

BMI mean/SD (kg/m2)

Treatment, duration

Control group

Type of surgical,

No. of cycles

Fresh/frozen sperm

Spouse’s age (year)

Outcomes (PR, FR, IR) and final outcome (LBR)

Adverse events

Female

 Ulug 2005

58

32.2/5.2

21.09/1.3

HCG, HMG,

TI

IUI, IVF (ICSI)-ET, 53 cycles

n/a

n/a

PR 56.6%,

abortion,

14 days

n = 16

FR 73.9%,

multiple pregnancy

IR 32.4%

 

 Kumbak 2006

27

32.8/4.9

25.7/4.5

gonadotrophins,

UI

IVF (ICSI)-ET,

n/a

n/a

PR 59.3%,

multiple pregnancy

14 days

n = 39

27 cycles

FR 89%,

IR 36.5%

 Yildirim 2010

13

31.3/5.6

25.3/3.1

gonadotrophins,

TI

IVF (ICSI)-ET,

n/a

n/a

PR 80%,

abortion

13 days

n = 20

13 cycles

FR 81.9%,

IR 38.3%,

LBR 50%

 Dokuzeylul 2010

57

≤37

n/a

gonadotrophins,

normal control

IVF (ICSI)-ET,

n/a

n/a

PR 56.14%,

n/a

14 days

n = 95

57 cycles

IR 36.7%

 Caragia 2012

17

32.96/3.976

n/a

FSH, LH,

TI/MI/UI

IVF (ICSI)-ET,

n/a

n/a

PR 55.6%,

no adverse events

16 days

N = 56/56/56

28 cycles

FR 55.4%,

LBR 54%

 Ghaffari 2013

81

33.5/5.3

26.1/4.0

HMG, HCG, P, E2,

TI

IVF (ICSI)-ET,

n/a

n/a

PR 19.4%,

abortion,

14 days

n = 89

72 cycles

FR 61.2%,

multiple pregnancy

IR 40%,

 

LBR 15.2%

 

 Pandurangi 2015

7

27

25.29/3.77

HMG, uFSH,

n/a

IUI, IVF (ICSI)-ET, 19 cycles

n/a

n/a

PR 31.6%,

abortion,

29 days

FR 85%,

multiple pregnancy

LBR 85.7%

 Yilmaz 2015

33

32.5/4.73

26/

3.81

HMG, HCG, recFSH, P,12 days

MI

IVF (ICSI)-ET,

n/a

n/a

PR 30%

n/a

n = 47

33 cycles

 Jiang 2017

46

30.9/3.9

21.26/1.89

HCG, HMG,

TI

IUI, IVF (ICSI)-ET, 42 cycles

n/a

n/a

PR 59.52%,

abortion,

13 days

n = 71

FR 82.13%,

multiple pregnancy

IR 41.46%

 

 Mumusoglu 2017

57

30.6/5.1

25.6/4.5

FSH,

TI

IVF (ICSI)-ET,

n/a

n/a

PR 36.8%,

abortion

11 days

n = 114

57 cycles

IR 34.4%,

LBR 36.8%

 Kuroda 2018

79

32.6/0.5

18/0.3

HCG, HMG,

n/a

IVF (ICSI)-ET,

n/a

n/a

PR 59.3%,

abortion

12.2 days

117 cycles

LBR 45.9%

Male

 Fahmy 2004

15

38.71/6.2

n/a

HCG, HMG,

n/a

TESE+IVF (ICSI)-ET,

n/a

n/a

PR 16.7%,

multiple pregnancy

6 months

17 cycles

FR 41.7%

 Zorn 2005

4

37.75

n/a

HCG, HMG,

n/a

IVF (ICSI)-ET,

fresh/

31.5

PR 33.3%,

no adverse events

13.25 months

9 cycles

frozen sperm

IR 21%

 Bakircioglu 2007

25

34.5/5.2

n/a

HCG,

n/a

TESE+IVF (ICSI)-ET,

fresh/

n/a

PR 54.5%

abortion

9.96 months

22 cycles

frozen sperm

 Akarsu 2009

4

36.25

n/a

HCG, HMG,

n/a

TESE+IVF (ICSI)-ET,

fresh/

29.5

PR 16.7%,

abortion,

9.96 months

18 cycles

frozen sperm

FR 41.8%,

multiple pregnancy

LBR 75%

 

 Resorlu 2009

17

30.1

n/a

HCG, FSH,

n/a

IVF (ICSI)-ET,

fresh

n/a

PR 54.5%

n/a

24 months

11 cycles

sperm

 Dokuzeylul 2010

31

34.82

n/a

HCG, HMG,

n/a

TESE+IVF (ICSI)-ET,

n/a

n/a

PR 51.7%,

abortion,

6 months

29 cycles

FR 83%,

multiple pregnancy

LBR 41.3%

 

 Bakircioglu 2012

12

40.2

n/a

HCG, FSH,

n/a

TESE+IVF (ICSI)-ET,

n/a

n/a

PR 66.7%,

multiple pregnancy

15.3 months

9 cycles

LBR 77.8%

 Sahin 2012

65

n/a

n/a

gonadotrophins,

n/a

IVF (ICSI)-ET,

n/a

n/a

PR 43.9%,

n/a

10.2 months

57 cycles

LBR 60%

 Basar 2017

61

35.8/5.64

n/a

HCG, HMG,

n/a

TESE+IVF (ICSI)-ET,

fresh/

n/a

PR 47.1%,

n/a

n/a

119 cycles

frozen sperm

LBR 62.3%

  1. TI = tubal factor infertility; MI = male factor infertility; UI = unexplained infertility; PR = pregnancy rate; FR = fertilization rate; IR = implantation rate; LBR = live birth rate