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Table 3 Independent Prognostic Factors

From: A modified M-stage classification based on the metastatic patterns of pancreatic neuroendocrine neoplasms: a population-based study

 

Univariate

Multivariate

HR and 95% CI

P-value

HR and 95% CI

P-value

Age (years)

  ≤ 60

Reference

Reference

  > 60

1.875 (1.595–2.204)

< 0.001

1.744 (1.479–2.055)

< 0.001

Sex

 Male

Reference

Reference

 Female

0.808 (0.691–0.945)

0.008

0.850 (0.726–0.996)

0.044

Race

 White

Reference

Reference

 Black

1.345 (1.082–1.670)

0.007

1.247 (0.998–1.558)

0.052

 Other

0.715 (0.527–0.970)

0.031

0.767 (0.565–1.043)

0.090

Size (cm)

  ≤ 2

Reference

Reference

  > 2

2.889 (2.241–3.724)

< 0.001

1.322 (1.009–1.731)

0.043

 Unclear

6.799(5.110–9.047)

< 0.001

1.547(1.129–2.119)

0.007

Primary Site

a

 Head

Reference

 

 Body

0.684(0.530–0.884)

0.004

  

 Tail

0.682(0.556–0.836)

< 0.001

  

 Other

1.128(0.929–1.368)

0.223

  

Differentiation

 Well

Reference

Reference

 Moderately

1.557 (1.095–2.215)

0.014

1.049 (0.735–1.498)

0.791

 Poorly

7.414 (5.608–9.803)

< 0.001

3.349 (2.498–4.489)

< 0.001

 Undifferentiated

9.494 (6.113–14.743)

< 0.001

3.166 (2.000–5.011)

< 0.001

 Unclear

5.136 (4.179–6.311)

< 0.001

1.626 (1.290–2.048)

< 0.001

T-stage

a

 T1

Reference

 

 T2

3.434(2.474–4.766)

< 0.001

  

 T3

3.353(2.399–4.688)

< 0.001

  

 T4

7.082(4.867–10.306)

< 0.001

  

 Tx

9.288(6.696–12.882)

< 0.001

  

N-stage

 N0

Reference

Reference

 N1

1.679 (1.415–1.993)

< 0.001

1.304 (1.092–1.557)

0.003

 Nx

3.732 (3.019–4.613)

< 0.001

1.452 (1.152–1.829)

0.002

Surgery

 Yes

Reference

Reference

 No

8.556 (6.941–10.548)

< 0.001

3.901 (3.013–5.050)

< 0.001

 Unclear

1.991 (0.812–4.883)

0.133

1.487 (0.601–3.680)

0.391

Radiation

a

 Yes

Reference

 

 No

1.984(1.511–2.603)

< 0.001

  

 Unclear

0.939(0.420–2.098)

0.878

  

mM-stage

 mM0-stage

Reference

Reference

 mM1-stage

4.520 (3.789–5.393)

< 0.001

1.643 (1.339–2.016)

< 0.001

 mM2-stage

8.199(6.380–10.537)

< 0.001

2.249(1.704–2.968)

< 0.001

 mM3-stage

16.356 (10.266–26.059)

< 0.001

5.034 (3.110–8.150)

< 0.001

  1. avariables excluded by multivariate forward stepwise cox regression
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BMC Endocrine Disorders

ISSN: 1472-6823

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