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Table 3 Estimated haplotype distributions in the metabolic syndrome (MetS) and control groups

From: Estrogen receptor 1 gene polymorphisms are associated with metabolic syndrome in postmenopausal women in China

SNP

Haplotype

MetS (freq.)

Control (freq.)

Global p-value

p-value

ESR1

A-C

65.15 (0.217)

76.73 (0.249)

0.022

0.351

XbaI-PvuII

A-T

65.85 (0.220)

94.27 (0.306)

 

0.015

G-C

93.85 (0.313)

71.27 (0.231)

 

0.024

G-T

75.15 (0.250)

65.73 (0.213)

 

0.279

ESR2

A-A

37.99 (0.127)

25.20 (0.082)

0.271

0.070

1082A > G-1730A > G

A-G

63.01 (0.210)

73.8 (0.240)

 

0.383

G-A

62.01 (0.207)

70.8 (0.230)

 

0.489

G-G

136.99 (0.457)

138.20 (0.44)

 

0.845

  1. Abbreviation: SNP single-nucleotide polymorphism
  2. Haplotypes have frequencies ≥3% in the MetS and control groups
  3. p < 0.05 indicated statistical significance
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BMC Endocrine Disorders

ISSN: 1472-6823

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