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Table 2 Allele frequencies and genotype distributions of ESR1 and ESR2 gene polymorphisms in the metabolic syndrome (MetS) and control groups

From: Estrogen receptor 1 gene polymorphisms are associated with metabolic syndrome in postmenopausal women in China

Variables

MetS

Control

P

OR(95 % CI)a

n (%)

n (%)

(n = 150)

(n = 154)

ESR1

XbaI (A > G)

 A allele

131 (43.7)

171 (55.5)

  

 G allele

169 (56.3)

137 (44.5)

0.004

1.610 (1.169, 2.18)

 1 (AA)

29 (19.3)

45 (29.2)

  

 2 (AG)

73 (48.7)

81 (52.6)

0.894

1.044 (0.556, 1.960)

 3 (GG)

48 (32.0)

28 (18.2)

0.109

2.660 (0.874, 3.829)

PVUII (T > C)

 T allele

143 (47.7)

157 (52.3)

  

 C allele

158 (51.3)

150 (48.7)

0.223

1.219 (0.887, 1.676)

 1 (TT)

31 (20.7)

38 (24.7)

  

 2 (TC)

79 (52.7)

84 (54.5)

0.012

2.440 (1.216, 4.897)

 3 (CC)

40 (26.7)

32 (20.8)

0.038

2.288 (1.045, 5.009)

ESR2

RsaI (B5) (1082A > G)

 A allele

101 (33.7)

99 (32.1)

  

 G allele

199 (66.3)

209 (67.9)

0.689

1.071 (0.764, 1.503)

 1 (AA)

20 (13.3)

18 (11.7)

  

 2 (AG)

61 (40.7)

63 (40.9)

0.863

1.074 (0.476, 2.426)

 3 (GG)

69 (46.0)

73 (47.4)

0.834

0.851 (0.412, 2.044)

AluI (B8) (1730A > G)

 A allele

100 (33.3)

96 (31.2)

  

 G allele

200 (66.7)

212 (68.8)

0.568

1.104 (0.786, 1.552)

 1 (AA)

21 (14.0)

20 (13.0)

  

 2 (AG)

58 (38.7)

56 (36.4)

0.225

0.592 (0.254, 1.382)

 3 (GG)

71 (47.3)

78 (50.6)

0.172

0.567 (0.251, 1.281)

  1. Abbreviations: CI confidence interval, OR odds ratio, NA not available
  2. OR OR value of rectified BMI and waist circumference for every allele
  3. a95% of the 95% CI for the OR CI
  4. p < 0.05 indicated statistical significance