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Table 5 Correlations between IGF-1 levels and demographic and pathological features after adjusting for bone age by group

From: Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

Variables

ar” with IGF1 (ng/ml)

Total (n = 489)

Control (n = 225)

CPP (n = 264)

Chronological age, years

0.016

0.143e

0.204d

Bone age, years

BA/CA ratio

−0.035

− 0.118

− 0.195d

Age of onset, years

− 0.170

0.143e

− 0.067

Z-scores of heightb

0.021

0.145e

0.185d

Z-scores of weightb

0.041

0.109

0.244c

Z-scores of BMIb

0.069

0.015

0.233c

E2, pmol/l

0.112e

−0.141e

0.160e

FSH, U/l

0.049

−0.297c

0.040

LH, U/l

0.419c

−0.222c

0.362c

GH, ng/ml

0.159d

0.221d

0.080

  1. aAdjusted r”: correlation with adjustment for BA (bone age)
  2. bZ-scores calculated with WHO Child Growth Standards for children up to 5 years old [25] and WHO standards for children older than 5 years [26]
  3. c,d,eCorrelations are significant at the 0.001, 0.01, and 0.05 levels (2-tailed)