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Table 3 Correlations of IGF-1 levels with demographic and pathological features with and without BMI adjustment by group

From: Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

Variables

r with IGF1 (ng/ml)

aAdjusted r’ with IGF1 (ng/ml)

Total (n = 489)

Control (n = 225)

CPP (n = 264)

Total (n = 485)

Control (n = 221)

CPP (n = 261)

Chronological age, years

0.275c

0.276c

0.466c

0.247c

0.259c

0.434c

Bone age, years

0.429c

0.172c

0.423c

0.386c

0.159e

0.390c

BA/CA ratio

0.292c

−0.015

−0.113

0.253c

−0.023

− 0.113

Age of onset, years

−0.019

0.141e

0.224c

0.053

0.225d

0.266c

Z-scores of heighta

0.276c

0.160e

0.486c

0.289c

0.147e

0.411c

Z-scores of weighta

0.293c

0.151

0.475c

0.299c

0.120

0.435c

Z-scores of BMIa

0.263c

0.157e

0.464c

–

–

–

E2, pmol/l

0.165c

0.165e

0.273c

0.159c

0.164e

0.254c

FSH, U/l

0.045

−0.283c

−0.136e

0.037

−0.303c

− 0.115

LH, U/l

0.523c

0.172c

0.447c

0.496c

0.101

0.425c

GH, ng/ml

0.176d

0.281d

0.111

0.199c

0.297c

0.131e

  1. aAdjusted r’: correlation with adjustment for BMI
  2. bZ-scores calculated with WHO Child Growth Standards for children up to 5 years old [25] and WHO 2007 reference for children older than 5 years [26]
  3. c, d, eCorrelations are significant at the 0.001, 0.01, and 0.05 levels (2-tailed)