Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls

Table 2 Demographic and clinical characteristics of CPP and control groups

Variables	Total (n = 489)	Control group (n = 225)	CPP group (n = 264)	p-value
Chronological age (CA), years	8.61 ± 1.36	8.75 ± 1.55	8.49 ± 1.16	0.199
Bone age (BA), years	9.70 ± 1.98	8.75 ± 2.14	10.51 ± 1.39	< 0.001*
BA/CA ratio	1.13 ± 0.18	1 ± 0.17	1.24 ± 0.08	< 0.001*
Age of onset, years	7.63 ± 1.18	7.99 ± 1.44	7.32 ± 0.77	< 0.001*
Height, cm	136.20 ± 10.76	131.3 ± 10.07	140.38 ± 9.5	< 0.001*
Z-scores of height^a	130.12 ± 8.24	0.09 ± 1.02	1.86 ± 1.40	0.078
Weight, kg	34.00 ± 9.44	30.44 ± 8.7	37.03 ± 8.99	< 0.001*
Z-scores of weight^a	26.26 ± 3.24	26.26 ± 3.11	26.71 ± 3.33	0.137
BMI	18.02 ± 3.14	17.4 ± 3.3	18.55 ± 2.91	< 0.001*
Z-scores of BMI^a	16.02 ± 0.58	16.10 ± 0.72	15.96 ± 0.41	0.008*
E2, pmol/l	32.74 ± 35.39	32.07 ± 48.24	33.31 ± 18.58	< 0.001*
FSH, U/l	14.40 ± 9.23	10.12 ± 8.03	18.05 ± 8.61	< 0.001*
LH, U/l	23.54 ± 30.70	5.62 ± 12.61	38.82 ± 33.23	< 0.001*
GH, ng/ml	3.43 ± 5.05	3.3 ± 5.22	3.55 ± 4.91	0.320
IGF-1, ng/ml	321.56 ± 125.87	257.46 ± 104.08	376.18 ± 116.88	< 0.001*
IGFBP-3, ng/ml	2282.02 ± 1167.12	1873.12 ± 1441.39	2630.51 ± 702.17	< 0.001*

*p < 0.05
^aZ-scores calculated with WHO Child Growth Standards for children up to 5 years old [25] and WHO 2007 reference for children older than 5 years [26]

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