Table 1 Variables and Definitions of Pre-Specified Variables and Potential Confounders for Analysis

 Age^a,b

≤ 65 years, >  65 years

 Gender^a,b

Male, Female

 Race/ethnicity ^a,b

White, Black/Other

 Treatment assignment ^a,b

IV rt-PA + Endovascular therapy, IV rt-PA

 Baseline stroke severity ^a,b

NIHSS < 20, NIHSS ≥20

 Ischemic stroke sub-type ^a,b

Large-artery atherosclerosis, Cardioembolic, Small-artery occlusion/Other/Unknown

 Baseline systolic blood ressure ^a,b

<  140 mmHg, ≥ 140 mmHg

 Baseline diastolic blood pressure ^a,b

in mmHg

 Baseline glucose ^a,b

in mmol/L

 History of previous stroke ^a,b

Yes, No

 History of atrial fibrillation ^a,b

Yes, No

 History of coronary artery disease ^a,b

Yes, No

 History of hypertension ^a,b

Yes, No

 Smoking status ^a,b

Current smoker, Former/Never smoker

 Alcohol use ^a,b

Current drinker, Former/Never drinker