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Table 4 The available case reports of CS with bilateral adrenal adenomas

From: ACTH-independent Cushing’s syndrome with bilateral cortisol-secreting adrenal adenomas: a case report and review of literatures

Study ID Country Age (years) Gender Lesions size (cm) Preoperative diagnostic technique
Onset Diag. right left
1963 Chappell, AG. NM 43 47 Female 3.0, 1.5 3.0 Left AVS and clinical manifestation
1985 Mimou N. Japan NM 43 Female 2.0 2.5 AVS without correction and Adrenocortical scintigraphy with 75Se-Scintadren
1995 Dinneen SF. America 49 69 Female 3.1 2.1 AVS without correction
1997 Makino, S. Japan 35 45 Female 2.5, 2.0 2.4 Adrenocortical scintigraphy with 131I-adosterol
1997 Tamura, H. Japan 43 48 Female 3.5 2.4 Adrenocortical scintigraphy with 131I-adosterol
2003 Nomura, K. Japan 33 37 Female 1.8 1.6 Adrenocortical scintigraphy with 131I-NP-59
2004 Tung SC. Taiwan 24 33 Female 3.0 3.0 Adrenocortical scintigraphy with 131I-NP-59
2006 Desai, N. America 30 30 Female 2.0 3.0 Iodocholesterol scan
2006 Inoue T. Japan 39 41 Female 2.0 2.4 Adrenocortical scintigraphy
2007 Domino, JP. Singapore NM 35 Female 1.8 2.2 AVS adjusted by aldosterone
2008 Oki, Kl. Japan 35 50 Female 1.1 1.0 AVS adjusted by aldosterone and Adrenocortical scintigraphy with 131I-adosterol
2012 Martins, RG. UK 51 59 Female 2.8 2.6 AVS without correction
2013 Ku, EJ. Korea 45 48 Female 2.8 2.3, 1.7 AVS without correction
2014 Yasuda, A. Japan 53 63 Male 2.4 2.5 AVS without correction and Adrenocortical scintigraphy with 131I-adosterol
2015 Monno, S. Japan 35 39 Female 2.4 3.1 Adrenocortical scintigraphy with 131I-NP-59
Study ID Operation Cut surface Functional side
right left
1963 Chappell, AG. Left, right total adrenalectomy (2 months later) Yellow NM NM
1985 Mimou N. Bilateral total adrenalectomy Dark brown Brownish-yellow Bilateral adenomas
1995 Dinneen SF. Bilateral total adrenalectomy NM NM Bilateral adenomas
1997 Makino, S. Bilateral total adrenalectomy Yellow, Black Yellow Left adenoma, the black right adenoma
1997 Tamura, H. Bilateral total adrenalectomy Brown NM Bilateral adenomas
2003 Nomura, K. Bilateral subtotal adrenalectomy Black Black Bilateral adenomas
2004 Tung SC. Right, left total adrenalectomy (9 years later) Yellow Yellow Bilateral adenomas
2006 Desai, N. Bilateral total adrenalectomy Yellow/ tan Yellow/ tan Bilateral adenomas
2006 Inoue T. Bilateral partial adrenalectomy Yellowish-brown Yellowish-brown Bilateral adenomas
2007 Domino, JP. Right total adrenalectomy, left partial adrenalectomy NM NM Bilateral adenomas
2008 Oki, Kl. Left partial adrenalectomy, right total adrenalectomy Golden yellow NM Bilateral adenomas
2012 Martins, RG. Bilateral total adrenalectomy NM NM Bilateral adenomas
2013 Ku, EJ. Bilateral total adrenalectomy Brown Light brown Bilateral adenomas
2014 Yasuda, A. Left total adrenalectomy, right partial adrenalectomy NM NM Bilateral adenomas
2015 Monno, S. Left, right total adrenalectomy (3 months later) Yellow Golden Bilateral adenomas
  1. AVS adrenal venous sampling, CS Cushing’s syndrome, NM not mentioned, 75Se-Scintadren 6-methyl-75Se-selenomethyl-19-norcholeste-5(10)-en-3ß-ol, 131I-NP-59 131I-6β-iodomethyl-19-norcholesterol