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Table 4 The available case reports of CS with bilateral adrenal adenomas

From: ACTH-independent Cushing’s syndrome with bilateral cortisol-secreting adrenal adenomas: a case report and review of literatures

Study ID

Country

Age (years)

Gender

Lesions size (cm)

Preoperative diagnostic technique

Onset

Diag.

right

left

1963 Chappell, AG.

NM

43

47

Female

3.0, 1.5

3.0

Left AVS and clinical manifestation

1985 Mimou N.

Japan

NM

43

Female

2.0

2.5

AVS without correction and Adrenocortical scintigraphy with 75Se-Scintadren

1995 Dinneen SF.

America

49

69

Female

3.1

2.1

AVS without correction

1997 Makino, S.

Japan

35

45

Female

2.5, 2.0

2.4

Adrenocortical scintigraphy with 131I-adosterol

1997 Tamura, H.

Japan

43

48

Female

3.5

2.4

Adrenocortical scintigraphy with 131I-adosterol

2003 Nomura, K.

Japan

33

37

Female

1.8

1.6

Adrenocortical scintigraphy with 131I-NP-59

2004 Tung SC.

Taiwan

24

33

Female

3.0

3.0

Adrenocortical scintigraphy with 131I-NP-59

2006 Desai, N.

America

30

30

Female

2.0

3.0

Iodocholesterol scan

2006 Inoue T.

Japan

39

41

Female

2.0

2.4

Adrenocortical scintigraphy

2007 Domino, JP.

Singapore

NM

35

Female

1.8

2.2

AVS adjusted by aldosterone

2008 Oki, Kl.

Japan

35

50

Female

1.1

1.0

AVS adjusted by aldosterone and Adrenocortical scintigraphy with 131I-adosterol

2012 Martins, RG.

UK

51

59

Female

2.8

2.6

AVS without correction

2013 Ku, EJ.

Korea

45

48

Female

2.8

2.3, 1.7

AVS without correction

2014 Yasuda, A.

Japan

53

63

Male

2.4

2.5

AVS without correction and Adrenocortical scintigraphy with 131I-adosterol

2015 Monno, S.

Japan

35

39

Female

2.4

3.1

Adrenocortical scintigraphy with 131I-NP-59

Study ID

Operation

Cut surface

Functional side

right

left

1963 Chappell, AG.

Left, right total adrenalectomy (2 months later)

Yellow

NM

NM

1985 Mimou N.

Bilateral total adrenalectomy

Dark brown

Brownish-yellow

Bilateral adenomas

1995 Dinneen SF.

Bilateral total adrenalectomy

NM

NM

Bilateral adenomas

1997 Makino, S.

Bilateral total adrenalectomy

Yellow, Black

Yellow

Left adenoma, the black right adenoma

1997 Tamura, H.

Bilateral total adrenalectomy

Brown

NM

Bilateral adenomas

2003 Nomura, K.

Bilateral subtotal adrenalectomy

Black

Black

Bilateral adenomas

2004 Tung SC.

Right, left total adrenalectomy (9 years later)

Yellow

Yellow

Bilateral adenomas

2006 Desai, N.

Bilateral total adrenalectomy

Yellow/ tan

Yellow/ tan

Bilateral adenomas

2006 Inoue T.

Bilateral partial adrenalectomy

Yellowish-brown

Yellowish-brown

Bilateral adenomas

2007 Domino, JP.

Right total adrenalectomy, left partial adrenalectomy

NM

NM

Bilateral adenomas

2008 Oki, Kl.

Left partial adrenalectomy, right total adrenalectomy

Golden yellow

NM

Bilateral adenomas

2012 Martins, RG.

Bilateral total adrenalectomy

NM

NM

Bilateral adenomas

2013 Ku, EJ.

Bilateral total adrenalectomy

Brown

Light brown

Bilateral adenomas

2014 Yasuda, A.

Left total adrenalectomy, right partial adrenalectomy

NM

NM

Bilateral adenomas

2015 Monno, S.

Left, right total adrenalectomy (3 months later)

Yellow

Golden

Bilateral adenomas

  1. AVS adrenal venous sampling, CS Cushing’s syndrome, NM not mentioned, 75Se-Scintadren 6-methyl-75Se-selenomethyl-19-norcholeste-5(10)-en-3ß-ol, 131I-NP-59 131I-6β-iodomethyl-19-norcholesterol