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Table 2 Hormonal status, biomarkers of inflammation and oxidative stress at baseline and after the 12-week intervention in subjects with polycystic ovary syndrome

From: The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

 

Placebo group (n = 30)

Synbiotic group (n = 30)

pa

 

Baseline

End-of-trial

Change

Baseline

End-of-trial

Change

Total testosterone (ng/mL)

2.4 ± 1.2

2.3 ± 1.0

−0.1 ± 0.5

2.8 ± 1.3

2.4 ± 0.9

−0.4 ± 0.9

0.09

SHBG (nmol/L)

38.3 ± 17.3

38.8 ± 17.6

0.5 ± 5.4

37.3 ± 13.1

57.1 ± 48.6

19.8 ± 47.3

0.01

FAI

0.27 ± 0.21

0.25 ± 0.16

−0.01 ± 0.08

0.33 ± 0.36

0.21 ± 0.14

−0.12 ± 0.29

0.01

mF-G scores

15.1 ± 3.8

15.0 ± 3.7

−0.1 ± 0.5

15.3 ± 5.6

14.0 ± 4.9

−1.3 ± 2.5

0.01

DHEAS (μg/mL)

2.6 ± 1.3

2.5 ± 1.1

−0.1 ± 0.4

2.6 ± 1.5

2.2 ± 0.8

−0.4 ± 1.1

0.40

hs-CRP (ng/mL)

2990.7 ± 2510.7

3326.0 ± 2791.1

335.3 ± 2466.9

2920.0 ± 2251.2

1970.0 ± 1442.0

−950.0 ± 2246.6

0.02

NO (μmol/L)

40.5 ± 8.7

40.8 ± 9.3

0.3 ± 9.1

39.0 ± 3.1

44.5 ± 5.0

5.5 ± 4.8

0.006

TAC (mmol/L)

868.7 ± 158.4

877.9 ± 149.9

9.2 ± 119.3

773.1 ± 38.7

818.2 ± 57.5

45.1 ± 51.8

0.13

GSH (μmol/L)

494.2 ± 85.5

521.5 ± 117.2

27.3 ± 117.8

498.9 ± 56.8

523.5 ± 53.4

24.7 ± 58.7

0.91

MDA (μmol/L)

2.2 ± 0.7

2.7 ± 1.2

0.5 ± 1.4

2.3 ± 0.4

2.1 ± 0.4

−0.2 ± 0.1

0.05

  1. All values are means± SDs
  2. aP values represent the time × group interaction (computed by analysis of the one-way repeated measures ANOVA)
  3. DHEAS dehydroepiandrosterone sulfate, FAI free androgen index, GSH total glutathione, hs-CRP high-sensitivity C-reactive protein, mF-G modified Ferriman Gallwey, MDA malondialdehyde, NO nitric oxide, SHBG sex hormone-binding globulin, TAC total antioxidant capacity