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Table 2 Hormonal status, biomarkers of inflammation and oxidative stress at baseline and after the 12-week intervention in subjects with polycystic ovary syndrome

From: The effects of synbiotic supplementation on hormonal status, biomarkers of inflammation and oxidative stress in subjects with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

  Placebo group (n = 30) Synbiotic group (n = 30) pa
  Baseline End-of-trial Change Baseline End-of-trial Change
Total testosterone (ng/mL) 2.4 ± 1.2 2.3 ± 1.0 −0.1 ± 0.5 2.8 ± 1.3 2.4 ± 0.9 −0.4 ± 0.9 0.09
SHBG (nmol/L) 38.3 ± 17.3 38.8 ± 17.6 0.5 ± 5.4 37.3 ± 13.1 57.1 ± 48.6 19.8 ± 47.3 0.01
FAI 0.27 ± 0.21 0.25 ± 0.16 −0.01 ± 0.08 0.33 ± 0.36 0.21 ± 0.14 −0.12 ± 0.29 0.01
mF-G scores 15.1 ± 3.8 15.0 ± 3.7 −0.1 ± 0.5 15.3 ± 5.6 14.0 ± 4.9 −1.3 ± 2.5 0.01
DHEAS (μg/mL) 2.6 ± 1.3 2.5 ± 1.1 −0.1 ± 0.4 2.6 ± 1.5 2.2 ± 0.8 −0.4 ± 1.1 0.40
hs-CRP (ng/mL) 2990.7 ± 2510.7 3326.0 ± 2791.1 335.3 ± 2466.9 2920.0 ± 2251.2 1970.0 ± 1442.0 −950.0 ± 2246.6 0.02
NO (μmol/L) 40.5 ± 8.7 40.8 ± 9.3 0.3 ± 9.1 39.0 ± 3.1 44.5 ± 5.0 5.5 ± 4.8 0.006
TAC (mmol/L) 868.7 ± 158.4 877.9 ± 149.9 9.2 ± 119.3 773.1 ± 38.7 818.2 ± 57.5 45.1 ± 51.8 0.13
GSH (μmol/L) 494.2 ± 85.5 521.5 ± 117.2 27.3 ± 117.8 498.9 ± 56.8 523.5 ± 53.4 24.7 ± 58.7 0.91
MDA (μmol/L) 2.2 ± 0.7 2.7 ± 1.2 0.5 ± 1.4 2.3 ± 0.4 2.1 ± 0.4 −0.2 ± 0.1 0.05
  1. All values are means± SDs
  2. aP values represent the time × group interaction (computed by analysis of the one-way repeated measures ANOVA)
  3. DHEAS dehydroepiandrosterone sulfate, FAI free androgen index, GSH total glutathione, hs-CRP high-sensitivity C-reactive protein, mF-G modified Ferriman Gallwey, MDA malondialdehyde, NO nitric oxide, SHBG sex hormone-binding globulin, TAC total antioxidant capacity