Table 1 Reported cases of ectopic adrenocorticotropin production that was suppressed by steroidogenesis inhibitorsa
Case | Author | Publication Year | Tumour Pathology | Drug | ACTH Suppression | ACTH levels a (pg/mL) | Cortisol Suppression | Cortisol levels a (μg/dL) | UFC Suppression | UFC levels a (μg/24 h) | Tumour Regression | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Before | After | Before | After | Before | After | |||||||||
1 | Beardwell [3] | 1981 | ND | MTP | + | 450 | 66 | + | > 72.5 | 6.8 | NA | NA | 19.9 | ND |
2 | Beardwell [3] | 1981 | ND | MTP | + | 98 | 62 | + | 51.5 | 16.6 | + | 366 | 26.2 | ND |
3 | Steen [9] | 1991 | thymic carcinoid | KTZ | + (partially) | 388 | 120 | + | > 72.5 | 18.9 | NA | NA | NA | - (operation) |
4 | Loh [5] | 1996 | pheochromocytoma | KTZ | + (partially) | 105 | 78 | NA | 51.9 | NA | + | 189 | 3.6 | - (operation) |
5 | Doi [4] | 2003 | islet cell carcinoma | octreotide or MTP | + | 735 | 13 | + | 145 | 1.9 | NA | NA | NA | - (operation) |
6 | Mizoguchi [6] | 2007 | pheochromocytoma | KTZ | + (partially) | 360 c | 78 | + | 180 c | < 1.0 c | NA | NA | NA | - (operation) |
7 | Sharma [8] | 2012 | ND | KTZ/MTP | + | 114 | 44 | NA | NA | NA | + | 455 | 27 | ND |
8 | Sharma [8] | 2012 | ND | KTZ/MTP | + | 108 | 7 | NA | NA | NA | + | 559 | 4 | ND |
9 | Sakuma [7] | 2016 | pheochromocytoma | phentolamine/landiolol/MTP | + | 995 | 18.4 | + | 85.6 | < 1.0 | + | 1250 | reduced | - (operation) |
10 | Our case | 2018 | (lung tumour) b | MTP | + | 192.9 | 48.2 | + | 73.1 | 7.6 | + | 6160 | 35.5 | + |