Parameters | Saxagliptin | Saxagliptin + Metformin | Metformin | ||||||
---|---|---|---|---|---|---|---|---|---|
Baseline | Treatment | Δ | Baseline | Treatment | Δ | Baseline | Treatment | Δ | |
LH, IU/L | 10.01 (6.21 to 13.81) | 7.8 (7 to 8.61) | −2.21 (− 5.54 to 1.12) | 9.62 (7.24 to 12.01) | 7.68 (6.86 to 8.5) | −1.94 (− 4.27 to 0.39) | 11.74 (8.59 to 14.89) | 7.55 (6.65 to 8.45)* | −4.19 (− 7.32 to − 1.05) |
FSH, IU/L | 6.27 (5.24 to 7.3) | 5.66 (5.16 to 6.16) | − 0.61 (− 1.62 to 0.4) | 7.66 (6.94 to 8.38) | 5.97 (5.57 to 6.37)** | − 1.69 (− 2.55 to − 0.83) | 8.18 (6.83 to 9.52) | 5.92 (5.31 to 6.53)** | − 2.26 (− 3.86 to − 0.66) |
T, nmol/L | 2.64 (2.33 to 2.96) | 2.13 (1.94 to 2.32)** | − 0.52 (− 0.69 to − 0.34)* | 2.61 (2.35 to 2.86) | 2.27 (2.09 to 2.45)* | −0.34 (− 0.52 to − 0.16)* | 2.6 (2.33 to 2.86) | 2.11 (1.97 to 2.26)** | −0.48 (− 0.65 to − 0.31) |
SHBG, nmol/L | 24.72 (17.14 to 32.29) | 29.62 (23.77 to 35.48) | 4.91 (1.56 to 8.25) | 25.51 (19.98 to 31.04) | 27.09 (22.76 to 31.41) | 1.57 (−0.8 to 3.95)* | 22.64 (15.73 to 29.54) | 26.98 (21.55 to 32.42) | 4.35 (1.72 to 6.97)* |
FAI | 15.82 (11.06 to 20.58) | 8.88 (6.4 to 11.35)* | −6.94 (− 9.83 to − 4.06)* | 11.72 (8.36 to 15.08) | 9.37 (7.57 to 11.16) | −2.35 (− 5.72 to 1.01)* | 14.84 (9.06 to 20.63) | 9.13 (7.38 to 10.88) | −5.72 (− 10.79 to −0.64) |