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Table 3 Lipid profile and inflammation before and after treatment in PCOS patients with new-onset T2DM

From: Comparison of glycemic control and β-cell function in new onset T2DM patients with PCOS of metformin and saxagliptin monotherapy or combination treatment

Parameters

Saxagliptin

Saxagliptin + Metformin

Metformin

 

Baseline

Treatment

Δ

Baseline

Treatment

Δ

Baseline

Treatment

Δ

TG, mmol/L

1.44 (1.16 to 1.72)

1.01 (0.92 to 1.09)**

− 0.43 (− 0.67 to − 0.2)

1.34 (1.19 to 1.5)

0.95 (0.86 to 1.04)**

− 0.39 (− 0.53 to − 0.25)

1.32 (1.05 to 1.59)

0.9 (0.79 to 1)**

−0.43 (− 0.62 to − 0.23)

TC, mmol/L

4.51 (4.2 to 4.81)

4.41 (4.19 to 4.64)

− 0.09 (− 0.21 to 0.02)**

4.8 (4.44 to 5.15)

4.52 (4.29 to − 4.75)**

−0.27 (− 0.5 to − 0.05)**

4.94 (4.57- to 5.31)

4.56 (4.28 to 4.84)**

−0.38 (− 0.54 to − 0.21)**

HDL-C, mmol/L

1.26 (1.16 to 1.37)

1.3 (1.24 to 1.36)

0.04 (− 0.03 to 0.1)

1.24 (1.14 to 1.35)

1.32 (1.23 to 1.4)

0.07 (−0.03 to 0.18)

1.35 (1.26 to 1.43)

1.41 (1.35 to 1.46)**

0.06 (0 to 0.12)

LDL-C, mmol/L

3.06 ± 0.7

2.87 ± 0.48*

−0.19 ± 0.36*

3.4 ± 0.73

2.98 ± 0.41**

− 0.42 ± 0.46*

3.32 ± 0.69

2.89 ± 0.45**

− 0.43 ± 0.35*

hsCRP, mg/L

3.97 (3.1 to 4.84)

2.23 (1.84 to 2.63)**

−1.74 (− 2.44 to − 1.03)

3.94 (3.09 to 4.8)

2.51 (2.22 to 2.81)**

−1.43 (− 2.08 to − 0.78)

4.02 (3.23 to 4.8)

3.03 (2.57 to 3.49)**

−0.99 (− 1.44 to − 0.54)

  1. Data are presented as mean ± SD or mean (95% CI). P-values based on the paired t-test for variables of normal distribution and the Wilcoxon signed-rank test for variables of skewed distribution, for differences between baseline and after the 24-week treatment; one-way ANOVA for variables of normal distribution and the Kruskal–Wallis test for variables of skewed distribution for differences among three groups. Δ denotes the changes after treatment compared with baseline. * P < 0.05 and ** P < 0.01 for changes before and after treatment in treatment columns, and for changes among three groups in Δ columns
  2. TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, hsCRP high-sensitivity C-reactive protein