Table 2 Parameters of glucose metabolism before and after treatment in PCOS patients
Parameters | Saxagliptin | Saxagliptin + Metformin | Metformin | ||||||
|---|---|---|---|---|---|---|---|---|---|
Baseline | Treatment | Δ | Baseline | Treatment | Δ | Baseline | Treatment | Δ | |
FBG, mmol/L | 5.63 (5.31 to 5.96) | 5.39 (5.15 to 5.62)* | −0.25 (− 0.49 to 0) | 5.84 (5.62 to 6.06) | 5.14 (5 to 5.27)** | − 0.7 (− 0.94 to − 0.46) | 5.62 (5.39 to 5.84) | 5.01 (4.88 to 5.14)** | −0.61 (− 0.86 to 0.35) |
2hBG, mmol/L | 14.73 (13.49 to 15.97) | 7.23 (6.61 to 7.85)** | −7.5 (− 8.62 to − 6.38) | 15.59 (14.26 to 16.92) | 7.4 (6.93 to 7.86)** | −8.2 (− 9.5 to − 6.9) | 14.64 (13.66 to 15.62) | 7.78 (7.36 to 8.2)** | −6.86 (− 8.02 to − 5.7) |
FINS, μIU/mL | 15.78 ± 6.7 | 11.55 ± 4.57** | − 4.23 ± 3.86 | 16.18 ± 5.3 | 10.67 ± 2.99** | −5.51 ± 2.92 | 14.34 ± 4.85 | 10.26 ± 1.74** | − 4.08 ± 4.45 |
2hINS, μIU/mL | 100.24 (80.63–119.85) | 63.24 (49.57–76.91)** | −37 (− 49.94 to − 24.06) | 111.82 (92.73 to 130.91) | 69.49 (58.84 to 80.14)** | − 42.33 (− 57.39 to − 27.27) | 100.26 (84.59 to 115.94) | 61.15 (49.87 to 72.43)** | −39.11 (− 53.1 to − 25.13) |
HbA1c, % | 7.4 ± 0.3 | 6.3 ± 0.2** | − 1.1 ± 0.4* | 7.4 ± 0.3 | 6.1 ± 0.2** | − 1.3 ± 0.3* | 7.3 ± 0.2 | 6.3 ± 0.3** | −1.1 ± 0.4* |
AUC glucose | 16.63 (15.65 to 17.62) | 11.7 (10.82 to 12.57)** | −4.94 (− 5.62 to − 4.26) | 17.18 (16.16 to 18.21) | 11.53 (10.92 to 12.14)** | −5.66 (− 6.44 to − 4.87) | 16.5 (15.81 to 17.19) | 11.19 (10.72 to 11.66)** | −5.31 (− 6.07 to − 4.56) |
AUC insulin | 129.93 (105.47 to 154.39) | 98.75 (83.41 to 114.1)** | −31.18 (− 44.49 to − 17.87) | 148.2 (128 to 168.41) | 120.77 (109.13 to 132.4)** | −27.44 (− 41.07 to − 13.81) | 122.66 (104.04 to 141.27) | 88.67 (76.72 to 100.62)** | −33.99 (− 48.58 to − 19.4) |
HOMA-IR | 4.03 (3.11 to 4.95) | 2.82 (2.21 to 3.42)** | −1.21 (− 1.71 to − 0.71) | 4.22 (3.55 to 4.89) | 2.45 (2.1 to 2.8)** | −1.77 (− 2.17 to − 1.38) | 3.56 (3.01 to 4.11) | 2.29 (2.1 to 2.47)** | −1.28 (− 1.82 to − 0.74) |
HOMA-IS | 157.2 (123.12 to 191.28) | 125.36 (101.75 to 148.96)* | −31.85 (− 61.16 to − 2.54) | 141.38 (119.5 to 163.25) | 133.3 (115.27 to 151.33) | −8.07 (−30.3 to 14.15) | 143.91 (116.96 to 170.86) | 141.32 (121.93 to 160.71) | −2.59 (− 28.77 to 23.58) |
Insulinogenic Index | 21.04 (15.19 to 26.89) | 20.32 (15.72 to 24.91) | −0.72 (− 4.99 to 3.54) | 23.65 (18.11 to 29.19) | 22.57 (18.23 to 26.91) | −1.08 (− 5.65 to 3.49) | 19.35 (14.84 to 23.87) | 18.76 (15.23 to 22.29) | −0.6 (− 6.15 to 4.96) |
Matsuda Index | 50 (39.81 to 60.18) | 78.6 (63.89 to 93.32)** | 28.61 (21.58 to 35.63) | 42.41 (35.12 to 49.7) | 71.37 (62.45 to 80.29)** | 28.96 (25.24 to 32.69) | 50.12 (44.35 to 55.89) | 84.82 (76.28 to 93.37)** | 35.26 (27.86 to 42.66) |
DI | 6.1 (4.42 to 7.77) | 8.7 (6.2 to 11.19)** | 2.6 (0.59 to 4.62) | 5.99 (4.5 to 7.49) | 9.57 (8.11 to 11.03)** | 3.57 (1.81 to 5.34) | 5.63 (4.23 to 7.02) | 8.71 (6.29 to 11.13)** | 3.09 (0.53 to 5.64) |