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Table 1 Baseline characteristics in PCOS patients with new-onset type 2 diabetes

From: Comparison of glycemic control and β-cell function in new onset T2DM patients with PCOS of metformin and saxagliptin monotherapy or combination treatment

Parameters

Saxagliptin

Saxagliptin + Metformin

Metformin

P-value

N

21

21

21

N/A

Age, years

30 ± 5

29 ± 5

28 ± 3

0.131

Weight, kg

70.4 (63.7–77.1)

69.3 (64.6–74.1)

67.9 (63.6–72.2)

0.886

BMI, kg/m2

27.2 (24.94–29.46)

26.38 (24.66–28.1)

26.4 (24.63–28.18)

0.904

WC, cm

86.8 (81.2–92.4)

84.7 (80.0–89.4)

82.8 (79.0–86.6)

0.395

WHR

0.88 ± 0.08

0.86 ± 0.06

0.85 ± 0.06

0.256

FAT%

36.13 (32.74–39.53)

35.12 (32.19–38.05)

33.6 (31.21–35.98)

0.397

FBG, mmol/L

5.63 (5.31–5.96)

5.84 (5.62–6.06)

5.62 (5.39–5.84)

0.166

2hBG, mmol/L

14.73 (13.49–15.97)

15.59 (14.26–16.92)

14.64 (13.66–15.62)

0.482

FINS, μIU/mL

15.78 ± 6.7

16.18 ± 5.3

14.34 ± 4.85

0.546

2hINS, μIU/mL

100.24 (80.63–119.85)

111.82 (92.73–130.91)

100.26 (84.59–115.94)

0.298

HbA1c, %

7.4 ± 0.3

7.4 ± 0.3

7.3 ± 0.2

0.668

AUC glucose

16.63 (15.65–17.62)

17.18 (16.16–18.21)

16.5 (15.81–17.19)

0.586

AUC insulin

129.93 (105.47–154.39)

148.2 (128–168.41)

122.66 (104.04–141.27)

0.152

TG, mmol/L

1.44 (1.16–1.72)

1.34 (1.19–1.5)

1.32 (1.05–1.59)

0.634

TC, mmol/L

4.51 (4.2–4.81)

4.8 (4.44–5.15)

4.94 (4.57–5.31)

0.175

HDL-C, mmol/L

1.26 (1.16–1.37)

1.24 (1.14–1.35)

1.35 (1.26–1.43)

0.167

LDL-C, mmol/L

3.06 ± 0.7

3.4 ± 0.73

3.32 ± 0.69

0.273

hsCRP, mg/L

3.97 (3.1–4.84)

3.94 (3.09–4.8)

4.02 (3.23–4.8)

0.937

LH, IU/L

14.2 (11.28–17.12)

11.57 (9.76–13.37)

12.53 (10.14–14.92)

0.434

FSH, IU/L

6.51 ± 2.04

6.76 ± 1.44

7.33 ± 2.36

0.393

T, nmol/L

2.64 ± 0.69

2.65 ± 0.67

2.64 ± 0.69

0.999

SHBG, nmol/L

24.72 (17.14–32.29)

30.1 (20.48–39.72)

22.64 (15.73–29.54)

0.382

FTI

15.82 (11.06–20.58)

11.72 (8.36–15.08)

16.91 (11.22–22.6)

0.274

  1. Data are presented as mean (95% CI); age, WHR, HbA1c, and LDL-C are presented as mean ± SD
  2. P-values are based on one-way ANOVA for variables of normal distribution and the Kruskal–Wallis test for variables of skewed distribution for differences among three groups
  3. BMI body mass index, WC waist circumference, WHR waist–hip ratio, FAT% body fat percentage, FBG fasting blood glucose, 2hBG 2-h glucose, FINS fasting insulin, 2hINS 2-h insulin, HbA1c hemoglobin A1c, AUC glucose glucose area under the curve during oral glucose tolerance test (OGTT), AUC insulin insulin area under the curve during OGTT, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, hsCRP high-sensitivity C-reactive protein, LH luteinizing hormone, FSH follicle-stimulating hormone, T total testosterone, SHBG sex hormone binding globulin, FTI Free testosterone index