Table 5 Meta-analysis of differences of Lumbar Spine BMD, Femoral Neck BMD, Lumbar Spine Z value and Femoral Neck Z value between each genotype of ERα XbaI and ERα PvuII polymorphism

ERα XbaI

Model

Model

N

WMD (95% CI)

P value

P value

I² (%)

N

WMD (95% CI)

P value

P value

I² (%)

 Overall

8

0.03 (−0.02, 0.08)

0.198

R

< 0.001

94.2

8

0.02 (− 0.00, 0.05)

0.086

R

< 0.001

94.1

 Caucasian

5

0.00 (−0.04, 0.04)

0.917

R

< 0.001

90.2

5

0.00 (−0.02, 0.02)

0.862

R

< 0.001

91.1

 Asian

3

0.11 (−0.16, 0.38)

0.414

R

< 0.001

97.8

3

0.07 (−0.07, 0.20)

0.326

R

< 0.001

97.3

 Overall

3

0.22 (−0.40, 0.83)

0.495

R

< 0.001

88.5

3

0.24 (0.00, 0.47)

0.046

R

0.041

68.6

 Caucasian

1

0.13 (0.05, 0.21)

0.001

R

–

–

1

0.18 (0.15, 0.21)

< 0.001

R

–

–

 Asian

2

−0.28 (−2.58, 2.02)

0.811

R

0.009

85.2

2

−0.23 (− 1.81, 1.36)

0.780

R

0.062

71.3

 Overall

6

0.03 (0.01, 0.05)

0.003

R

0.001

75.5

6

0.01 (−0.00, 0.03)

0.057

R

< 0.001

84.7

 Caucasian

5

0.03 (0.01, 0.05)

0.009

R

< 0.001

80.4

5

0.01 (−0.00, 0.03)

0.094

R

< 0.001

87.7

 Asian

1

0.03 (−0.01, 0.08)

0.110

R

–

–

1

0.01 (−0.02, 0.04)

0.350

R

–

–

 Overall

2

−0.38 (−2.56, 1.80)

0.733

R

< 0.001

99.2

2

0.25 (−0.07, 0.58)

0.130

R

0.001

91.6

 Caucasian

1

−1.48 (−1.57, −1.39)

< 0.001

R

–

–

1

0.10 (0.07, 0.13)

< 0.001

R

–

–

 Asian

1

0.74 (0.37, 1.11)

< 0.001

R

–

–

1

0.43 (0.24, 0.62)

< 0.001

R

–

–

ERα PvuII

Model

Model

N

WMD (95% CI)

P value

P value

I² (%)

N

WMD (95% CI)

P value

P value

I² (%)

 Overall

10

0.02 (− 0.01, 0.04)

0.216

R

< 0.001

95.5

10

−0.01 (− 0.02, − 0.00)

0.036

R

< 0.001

84.0

 Caucasian

5

0.01 (−0.04, 0.06)

0.793

R

< 0.001

95.5

5

−0.02 (− 0.03, 0.00)

0.106

R

< 0.001

84.9

 Asian

5

0.03 (−0.02, 0.08)

0.288

R

< 0.001

96.2

5

−0.00 (− 0.02, 0.02)

0.912

R

< 0.001

86.4

 Overall

3

0.11 (−0.55, 0.78)

0.742

R

< 0.001

98.7

3

0.13 (−0.40, 0.67)

0.623

R

< 0.001

95.9

 Caucasian

1

−0.07 (− 0.13, − 0.01)

0.031

R

–

–

1

− 0.16 (− 0.20, − 0.12)

< 0.001

R

–

–

 Asian

2

0.24 (−1.72, 2.20)

0.809

R

< 0.001

99.0

2

0.34 (−1.18, 1.85)

0.665

R

< 0.001

97.9

 Overall

8

−0.04 (− 0.09, 0.01)

0.135

R

< 0.001

99.3

8

−0.02 (− 0.04, 0.01)

0.132

R

< 0.001

98.2

 Caucasian

5

−0.06 (− 0.16, 0.05)

0.295

R

< 0.001

99.6

5

−0.03 (− 0.05, 0.00)

0.054

R

< 0.001

95.2

 Asian

3

−0.01 (− 0.02, − 0.01)

< 0.001

R

1.000

0.00

3

−0.00 (− 0.03, 0.02)

0.768

R

0.009

78.7

 Overall

2

−0.39 (−1.15, 0.37)

0.315

R

< 0.001

97.0

2

−0.39 (− 0.57, − 0.20)

< 0.001

R

0.024

80.3

 Caucasian

1

−0.01 (− 0.08, 0.05)

0.718

R

–

–

1

−0.31 (− 0.35, − 0.27)

< 0.001

R

–

–

 Asian

1

−0.79 (−1.05, − 0.53)

< 0.001

R

–

–

1

− 0.50 (− 0.66, − 0.34)

< 0.001

R

–

–