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Table 2 Change in metabolic parameters after treatment

From: The effects of metformin in type 1 diabetes mellitus

Variables

Metformin-insulin

n = 29

İnsulin-only

n = 29

p value

∆ Metabolic syndrome prevalence (%)

−8.9 ± 1.3

2.5 ± 0.6

0.028

∆ Body weight (kg)

−0.41 ± 2.44

0.13 ± 2.55

0.222

∆ Waist circumference (cm)

−0.34 ± 1.67

0.41 ± 1.61

0.384

∆ FPG (mg/dl)

−26.9 ± 54.2

0.7 ± 29.5

0.022

∆ PPG (mg/dl)

−43.1 ± 61.8

−3.1 ± 40.1

0.010

∆ HbA1c (%)

−0.8 ± 1.4

−0.3 ± 1.3

0.075

∆ Total cholesterol (mg/dl)

−2.78 ± 36.7

−2.20 ± 17.9

0.962

∆ Triglycerides (mg/dl)

−21.5 ± 98.6

−26.2 ± 75.5

0.855

∆ LDL-C (mg/dl)

−5.0 ± 27.6

−4.9 ± 23.8

0.899

∆ HDL-C (mg/dl)

0.43 ± 9.65

2.88 ± 9.50

0.522

∆ Systolic blood pressure (mmHg)

1.55 ± 11.02

6.72 ± 6.16

0.032

∆ Diastolic blood pressure (mmHg)

0.48 ± 6.41

4.82 ± 7.84

0.025

∆ Total daily insulin dose (IU/kg bodyweight/d)a

−0.03 (−0.39 ─ 0.28)

0.11 (−0.24 ─ 0.35)

0.006

  1. Data are shown as mean ± standard deviation (means ± SD) and amedian (min-max)
  2. The difference (∆) are shown as change in values before and after treatment (after value minus before value)
  3. Abbreviations: FPG fasting plasma glucose, HbA 1c hemoglobin A1c, PPG postprandial plasma glucose, HDL-C high density lipoprotein-cholesterol, LDL-C low density lipoprotein-cholesterol, IU international units
  4. Bold represents the significant p-values