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Table 3 Patient characteristics by presenting status and final biochemical control status

From: Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center

Final Biochemical Control

Presenting Uncontrolled Without Prior Treatment for Acromegaly

n = 40 (54.1%)

Presenting Uncontrolled with Prior Treatment for Acromegaly

n = 34 (45.9%)

All

N = 74

Controlled

n = 33 (82.5%)

Uncontrolled

n = 7 (17.5%)

Controlled

n = 17 (50.0%)

Uncontrolled

n = 17 (50.0%)

Age at index date, yeara

 mean

44.5

45.6

46.8

53.4

47.2

 (SD)

(15.9)

(14.5)

(12.9)

(17.7)

(15.6)

Age at diagnosis, yearb

 N

30

5

16

15

66

 mean

44.5

40.0

41.4

43.6

43.2

 (SD)

(15.9)

(13.6)

(12.1)

(16.1)

(14.7)

Years of follow-up at center

 mean

5.0

5.3

8.7

8.3

6.7

 (SD)

(4.7)

(2.7)

(6.3)

(5.3)

(5.3)

 min-max

0.3-23.0

2.2-9.4

0.2-21.3

0.6-20.2

0.2-23.0

 median

4.2

4.5

8.0

7.3

4.9

Tumor Sizec

  n

31

5

15

14

65

 Macroadenoma

  n

29

4

14

12

59

  (%)

(93.5)

(80.0)

(93.3)

(85.7)

(90.8)

 Microadenoma

  n

2

1

1

2

6

  (%)

(6.5)

(20.0)

(6.7)

(14.3)

(9.2)

Abnormal finding on MRI or CT

 n

21

4

7

8

40

 (%)

(63.6)

(57.1)

(41.2)

(47.1)

(54.1)

Hormonal Abnormalities

 Prolactin elevation

  n

0

0

0

1

1

  (%)

(0.0)

(0.0)

(0.0)

(5.9)

(1.4)

 Adrenal insufficiency

  n

2

2

1

2

7

  (%)

(6.1)

(28.6)

(5.9)

(11.8)

(9.5)

 Gonadal insufficiency

  n

4

1

4

0

9

  (%)

(12.1)

(14.3)

(23.5)

(0.0)

(12.2)

 Hypothyroidism

  n

3

1

2

4

10

  (%)

(9.1)

(14.3)

(11.8)

(23.5)

(13.5)

  1. aIndex date was defined as the first visit at the center;
  2. b35 patients had information about age at diagnosis in the presenting uncontrolled without prior treatment group; 31 patients had the information in the presenting uncontrolled with prior treatment group;
  3. c36 patients had tumor size available in the patient medical record in the presenting uncontrolled without prior treatment group; 29 patients had the information in the presenting uncontrolled with prior treatment group