Parameter | Metformin n = 20 | P-value | Rimonabant n = 10 | P-value | Orlistat n = 10 | P-value | Pioglitazone n = 10 | P-value | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 12 weeks | Baseline | 12 weeks | Baseline | 12 weeks | Baseline | 12 weeks | |||||
Weight (kg) | 103.8 ± 3.9 | 102.2 ± 4.1 | 0.08 | 104.6 ± 4.6 | 98.4 ± 4.7 | <0.01 | 103.1 ± 6.9 | 97.1 ± 6.1 | <0.01 | 96.3 ± 4.9 | 99.2 ± 5.1 | 0.06 |
BMI (kg/m2) | 35.7 ± 1.4 | 35.09 ± 1.5 | 0.08 | 36.86 ± 1.0 | 34.52 ± 1.0 | <0.01 | 37.4 ± 2.7 | 35.2 ± 2.4 | <0.01 | 36.2 ± 1.8 | 37.3 ± 1.8 | 0.06 |
FAI (%) | 20.5 ± 4.0 | 18.2 ± 3.0 | 0.04 | 26.6 ± 6.1 | 16.6 ± 4.1 | <0.01 | 16.4 ± 2.4 | 12.0 ± 2.4 | 0.01 | 18.1 ± 2.9 | 12.7 ± 1.6 | 0.02 |
ALT (U/L) | 20.5 ± 2.54 | 18.1 ± 1.93 | 0.14 | 30.8 ± 5.1 | 26.4 ± 6.0 | <0.01 | 13.2 ± 2.0 | 12.5 ± 1.6 | 0.49 | 20.4 ± 7.0 | 18.6 ± 3.0 | 0.58 |
HOMA-IR | 3.4 ± 0.7 | 3.4 ± 0.8 | 0.77 | 4.4 ± 0.5 | 3.4 ± 0.4 | 0.05 | 5.0 ± 0.8 | 3.7 ± 0.5 | 0.01 | 4.5 ± 0.8 | 2.5 ± 0.4 | <0.01 |
hsCRP (mg/l) | 4.2 ± 1.7 | 4.0 ± 1.3 | 0.9 | 5.6 ± 1.2 | 5.2 ± 1.2 | 0.7 | 6.2 ± 2.0 | 5.6 ± 2.0 | 0.6 | 7.2 ± 1.8 | 3.1 ± 0.8 | <0.01 |
TC | 6.0 ± 0.3 | 5.6± | 0.12 | 5.1 ± 0.3 | 4.7 ± 0.3 | 0.19 | 5.1 ± 1.2 | 4.6 ± 0.2 | 0.6 | 5.0 ± 0.4 | 5.1 ± 0.3 | 0.9 |
LDL-C | 3.9 ± 0.3 | 3.5 ± 0.3 | 0.06 | 3.3 ± 0.3 | 3.1 ± 0.3 | 0.21 | 3.1 ± 0.2 | 2.7 ± 0.2 | 0.08 | 3.1 ± 0.3 | 3.2 ± 0.4 | 0.8 |
HDL-C | 1.2 ± 0.2 | 1.2 ± 0.1 | 0.7 | 1.2 ± 0.2 | 1.1 ± 0.1 | 0.4 | 1.2 ± 0.05 | 1.2 ± 0.03 | 0.9 | 1.2 ± 0.06 | 1.4 ± 0.1 | 0.8 |
TG | 2.0 ± 0.3 | 1.9 ± 0.4 | 0.3 | 1.4 ± 0.2 | 1.3 ± 0.1 | 0.4 | 1.8 ± 0.2 | 1.7 ± 0.2 | 0.8 | 1.4 ± 0.2 | 1.2 ± 0.2 | 0/8 |