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Table 1 Anthropometric and metabolic data

From: Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss

Parameter Metformin n = 20 P-value Rimonabant n = 10 P-value Orlistat n = 10 P-value Pioglitazone n = 10 P-value
Baseline 12 weeks Baseline 12 weeks Baseline 12 weeks Baseline 12 weeks
Weight (kg) 103.8 ± 3.9 102.2 ± 4.1 0.08 104.6 ± 4.6 98.4 ± 4.7 <0.01 103.1 ± 6.9 97.1 ± 6.1 <0.01 96.3 ± 4.9 99.2 ± 5.1 0.06
BMI (kg/m2) 35.7 ± 1.4 35.09 ± 1.5 0.08 36.86 ± 1.0 34.52 ± 1.0 <0.01 37.4 ± 2.7 35.2 ± 2.4 <0.01 36.2 ± 1.8 37.3 ± 1.8 0.06
FAI (%) 20.5 ± 4.0 18.2 ± 3.0 0.04 26.6 ± 6.1 16.6 ± 4.1 <0.01 16.4 ± 2.4 12.0 ± 2.4 0.01 18.1 ± 2.9 12.7 ± 1.6 0.02
ALT (U/L) 20.5 ± 2.54 18.1 ± 1.93 0.14 30.8 ± 5.1 26.4 ± 6.0 <0.01 13.2 ± 2.0 12.5 ± 1.6 0.49 20.4 ± 7.0 18.6 ± 3.0 0.58
HOMA-IR 3.4 ± 0.7 3.4 ± 0.8 0.77 4.4 ± 0.5 3.4 ± 0.4 0.05 5.0 ± 0.8 3.7 ± 0.5 0.01 4.5 ± 0.8 2.5 ± 0.4 <0.01
hsCRP (mg/l) 4.2 ± 1.7 4.0 ± 1.3 0.9 5.6 ± 1.2 5.2 ± 1.2 0.7 6.2 ± 2.0 5.6 ± 2.0 0.6 7.2 ± 1.8 3.1 ± 0.8 <0.01
TC 6.0 ± 0.3 5.6± 0.12 5.1 ± 0.3 4.7 ± 0.3 0.19 5.1 ± 1.2 4.6 ± 0.2 0.6 5.0 ± 0.4 5.1 ± 0.3 0.9
LDL-C 3.9 ± 0.3 3.5 ± 0.3 0.06 3.3 ± 0.3 3.1 ± 0.3 0.21 3.1 ± 0.2 2.7 ± 0.2 0.08 3.1 ± 0.3 3.2 ± 0.4 0.8
HDL-C 1.2 ± 0.2 1.2 ± 0.1 0.7 1.2 ± 0.2 1.1 ± 0.1 0.4 1.2 ± 0.05 1.2 ± 0.03 0.9 1.2 ± 0.06 1.4 ± 0.1 0.8
TG 2.0 ± 0.3 1.9 ± 0.4 0.3 1.4 ± 0.2 1.3 ± 0.1 0.4 1.8 ± 0.2 1.7 ± 0.2 0.8 1.4 ± 0.2 1.2 ± 0.2 0/8
  1. BMI body mass index, FAI free androgen index, ALT alanine aminotransferase, HOMA-IR homeostasis model assessment of insulin resistance, hsCRP high-sensitivity C-reactive protein
  2. Data are presented as mean ± SD. All serum results are obtained from fasting variables. All variables were normally distributed. To convert values for glucose to milligrams per decilitre, divide by 0·056. To convert values for insulin to picomoles per litre, multiply by 6. To convert values for cholesterol to milligrams per decilitre, divide by 0·0259. To convert values for triglycerides to milligrams per decilitre, divide by 0·0113. To convert values for testosterone to nanograms per decilitre, divide by 0·03467. To convert values for SHBG to micrograms per decilitre, divide by 34·7. TC Total cholesterol, LDL-C, LDL-cholesterol, HDL-C, HDL cholesterol, TG, triglycerides FAI free androgen index