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Does left ventricular hypertrophy affect cognition and brain structural integrity in type 2 diabetes? Study design and rationale of the Diabetes and Dementia (D2) study

  • Sheila K. Patel1, 2,
  • Carolina Restrepo1,
  • Emilio Werden1,
  • Leonid Churilov1,
  • Elif I. Ekinci2, 3,
  • Piyush M. Srivastava2, 4,
  • Jay Ramchand2, 4,
  • Bryan Wai2, 4,
  • Brian Chambers2, 5,
  • Christopher J. O’Callaghan2, 6,
  • David Darby1,
  • Vladimir Hachinski7,
  • Toby Cumming1,
  • Geoff Donnan1,
  • Louise M. Burrell2, 4Email author and
  • Amy Brodtmann1, 2, 5Email author
Contributed equally
BMC Endocrine DisordersBMC series – open, inclusive and trusted201717:24

Received: 16 March 2017

Accepted: 31 March 2017

Published: 7 April 2017

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Open Peer Review reports

Pre-publication versions of this article and author comments to reviewers are available by contacting

Original Submission
16 Mar 2017 Submitted Original manuscript
19 Mar 2017 Author responded Author comments - sheila patel
Resubmission - Version 2
19 Mar 2017 Submitted Manuscript version 2
31 Mar 2017 Editorially accepted
7 Apr 2017 Article published 10.1186/s12902-017-0173-7

How does Open Peer Review work?

Open peer review is a system where authors know who the reviewers are, and the reviewers know who the authors are. If the manuscript is accepted, the named reviewer reports are published alongside the article. Pre-publication versions of the article and author comments to reviewers are available by contacting All previous versions of the manuscript and all author responses to the reviewers are also available.

You can find further information about the peer review system here.

Authors’ Affiliations

The Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, Austin Health
Department of Medicine, University of Melbourne, Austin Health
Austin Health Endocrine Centre
Department of Cardiology, Austin Health
Department of Neurology, Austin Health
Department of Clinical Pharmacology, Austin Health
Department of Clinical Neurological Sciences, London Health Sciences Centre, University of Western Ontario