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Table 4 Risk of diabetes according to quartiles of hs-CRP: stratified by baseline BMI

From: High-sensitive C-reactive protein and risk of incident type 2 diabetes: a case–control study nested within the Singapore Chinese Health Study

 

Quartiles of hs-CRPa

P for trendb

Per 1 log mg/L increase

Q1

Q2

Q3

Q4

Median (range)

0.4 (0.1–0.6)

0.9 (0.7–1.2)

1.6 (1.3–2.3)

3.6 (2.4–11.0)

  

BMI <23 kg/m2

 Cases/controls

37/109

42/84

48/68

59/57

  

 Model 1

1.00

1.49 (0.88–2.53)

2.08 (1.23–3.51)

2.95 (1.75–4.99)

<0.001

1.47 (1.22–1.77)

 Model 2

1.00

1.41 (0.82–2.43)

1.93 (1.12–3.32)

2.67 (1.54–4.60)

<0.001

1.42 (1.17–1.72)

 Model 3

1.00

1.27 (0.71–2.25)

1.38 (0.77–2.47)

2.07 (1.16–3.70)

0.02

1.29 (1.05–1.58)

BMI ≥23 kg/m2

 Cases/controls

41/45

65/55

102/70

177/83

  

 Model 1

1.00

1.39 (0.79–2.44)

1.74 (1.02–2.96)

2.62 (1.56–4.41)

<0.001

1.55 (1.29–1.86)

 Model 2

1.00

1.30 (0.73–2.33)

1.43 (0.82–2.50)

2.19 (1.28–3.78)

0.002

1.46 (1.21–1.77)

 Model 3

1.00

1.11 (0.60–2.05)

1.20 (0.67–2.15)

1.68 (0.95–2.97)

0.041

1.33 (1.09–1.63)

  1. Abbreviation: hs-CRP high-sensitive C-reactive protein, BMI body mass index, OR odds ratio, CI confidence interval
  2. aQuartiles of hs-CRP were created based on controls in the whole population
  3. bLinear trend was tested by using the median level of each quartile of hs-CRP as continuous variables
  4. Model 1: adjusted for age (continuous variable), sex, and dialect
  5. Model 2: model 1 plus education level, smoking status, alcohol intake, physical activity, hypertension, and fasting status
  6. Model 3: model 2 plus plasma triglycerides and HDL-cholesterol levels (both in quartiles)
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BMC Endocrine Disorders

ISSN: 1472-6823

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