Skip to main content

Table 3 Risk of diabetes according to sex-specific quartiles of hs-CRP: stratified by sex

From: High-sensitive C-reactive protein and risk of incident type 2 diabetes: a case–control study nested within the Singapore Chinese Health Study

 

Quartiles of hs-CRPa

P for trendb

Per 1 log mg/L increase

Q1

Q2

Q3

Q4

Men

 Median (range)

0.3 (0.12–0.4)

0.8 (0.5–1.1)

1.5 (1.2–2.0)

3.4 (2.1–11.0)

  

 Cases/controls

22/60

70/64

59/53

85/59

  

 Model 1

1.00

2.79 (1.54–5.05)

3.00 (1.60–5.63)

3.73 (2.04–6.79)

0.002

1.46 (1.21–1.75)

 Model 2

1.00

3.42 (1.77–6.61)

3.06 (1.53–6.13)

3.57 (1.80–7.11)

0.039

1.38 (1.12–1.70)

 Model 3

1.00

2.76 (1.40–5.47)

2.45 (1.20–5.03)

2.80 (1.38–5.69)

0.029

1.30 (1.05–1.61)

 Model 4

1.00

2.86 (1.36–6.01)

1.90 (0.86–4.19)

2.25 (1.06–4.79)

0.24

1.19 (0.94–1.49)

Women

 Median (range)

0.5 (0.12–0.7)

1.1 (0.8–1.3)

1.8 (1.4–2.5)

4.3 (2.6–11.0)

  

 Cases/controls

44/94

56/79

87/82

148/80

  

 Model 1

1.00

1.53 (0.91–2.57)

2.29 (1.38–3.80)

3.86 (2.39–6.21)

<0.001

1.72 (1.44–2.04)

 Model 2

1.00

1.37 (0.79–2.37)

2.00 (1.16–3.46)

3.32 (1.99–5.53)

<0.001

1.63 (1.36–1.96)

 Model 3

1.00

1.10 (0.61–2.00)

1.45 (0.80–2.66)

2.19 (1.24–3.85)

0.002

1.42 (1.16–1.73)

 Model 4

1.00

1.09 (0.54–2.20)

1.25 (0.63–2.47)

2.07 (1.07–3.99)

0.012

1.41 (1.12–1.78)

  1. Abbreviation: hs-CRP high-sensitive C-reactive protein, OR odds ratio, CI confidence interval
  2. aQuartiles of hs-CRP were created separately for men and women among controls
  3. bLinear trend was tested by using the median level of each quartile of hs-CRP as continuous variables
  4. Model 1: adjusted for age (continuous variable), matched on age (±3 years), sex, dialect, and date of blood collection (±6 months)
  5. Model 2: model 1 plus education level, smoking status, alcohol intake, physical activity, hypertension, and fasting status
  6. Model 3: model 2 plus adjusted for body mass index (continuous)
  7. Model 4: model 3 plus plasma triglycerides and HDL-cholesterol levels (both in quartiles)