Table 3 The impact of foot insensitivity on eGFR and progression to albuminuria longitudinally

Progression to albuminuria (N^a = 83 vs. 29)

11 (13.3%)

10 (34.5%)

0.012

Progression to macroalbuminuria (N^a = 112 vs. 50)

2 (1.8%)

7 (14.0%)

0.002

eGFR change (ml min⁻¹ 1.73 m⁻²) (N^a = 150 vs. 75)

−2.0 (−9.0 to 3.0)

−7.0 (−17.0 to −2.0)

0.001

eGFR change as % of baseline eGFR (%) (N^a = 150 vs. 75)

−3.0 (−10.0 to 3.6)%

−9.5 (−18.5 to −2.5)%

<0.001

Progression to albuminuria (N^a = 50 vs. 8)

5 (10.0%)

3 (37.5%)

0.071

Progression to macroalbuminuria (N^a = 67 vs. 20)

0 (0.0%)

4 (20.0%)

0.002

eGFR change (ml min⁻¹ 1.73 m⁻²)

(N^a = 94 vs. 29)

−3.0 (−9.0 to 3.3)

−10.0 (−17 to −3.0)

0.001

eGFR change as % of baseline eGFR (%) (N^a = 94 vs. 29)

−2.9 (−10.7 to 3.6)%

−12.2 (−19.0 to −4.4)

<0.001

Progression to albuminuria (N^a = 33 vs. 21)

6 (18.2%)

7 (33.3%)

0.204

Progression to macroalbuminuria (N^a = 45 vs. 30)

2 (4.4%)

3 (10.0%)

0.383

eGFR change (ml min⁻¹ 1.73 m⁻²)

(N^a = 56 vs. 46)

−2.0 (−8.0 to 2.0)

−5.5.0 (−15.0 to 1.3)

0.125

eGFR change as % of baseline eGFR (%) (N^a = 56 vs. 46)

−3.0 (−9.7 to 4.2)%

−7.7 (−18.6 to −2.5)%

0.091