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Table 2 Daily insulin doses for the modified intention-to-treat analysis population with last observation carried forward for missing observations at Week 24

From: A randomised, open-labelstudy of insulin glargine or neutral protamine Hagedorn insulin in Chinese paediatric patients with type 1 diabetes mellitus

  Insulin glargine NPH insulin
  n Mean ± SD Median n Mean ± SD Median
    (Q1, Q3)    (Q1, Q3)
Mean daily total insulin, units/kg/day ± SDa
 Baseline 107 0.84 ± 0.23 0.82 (0.67, 1.00) 53 0.87 ± 0.29 0.82 (0.70, 1.05)
 Week 24 106 0.91 ± 0.25 0.91 (0.73, 1.04) 50 1.08 ± 0.32 1.11 (0.86, 1.28)
 Changeb 106 0.08 ± 0.16 0.07 (–0.02, 0.17) 50 0.19 ± 0.26 0.18 (–0.00, 0.35)
 Week 24 (LOCF) 107 0.91 ± 0.25 0.91 (0.73, 1.04) 53 1.06 ± 0.32 1.06 (0.85, 1.26)
 Change (LOCF)b 107 0.07 ± 0.16 0.07 (–0.03, 0.17) 53 0.19 ± 0.26 0.16 (–0.00, 0.35)
LS Mean Difference −0.13 (0.03)
95% CI −0.19 to –0.06
Mean daily basal insulin, units/kg/day ± SDa
 Baseline 107 0.29 ± 0.09 0.28 (0.23, 0.34) 53 0.31 ± 0.13 0.32 (0.23, 0.38)
 Week 24 106 0.31 ± 0.09 0.29 (0.25, 0.37) 50 0.44 ± 0.16 0.44 (0.34, 0.52)
 Changeb 106 0.03 ± 0.07 0.02 (–0.01, 0.06) 50 0.12 ± 0.14 0.11 (0.04, 0.20)
 Week 24 (LOCF) 107 0.31 ± 0.09 0.29 (0.25, 0.38) 53 0.43 ± 0.16 0.43 (0.30, 0.50)
 Change (LOCF)b 107 0.02 ± 0.07 0.02 (–0.01, 0.06) 53 0.11 ± 0.14 0.11 (0.04, 0.20)
LS Mean Difference −0.01 (0.02)
95% CI −0.13 to –0.06
Mean daily bolus insulin, units/kg/day ± SD
 Baseline 107 0.55 ± 0.18 0.53 (0.42, 0.68) 52 0.58 ± 0.23 0.54 (0.40, 0.73)
 Week 24 106 0.60 ± 0.19 0.58 (0.48, 0.71) 49 0.64 ± 0.23 0.63 (0.46, 0.81)
 Changeb 106 0.05 ± 0.12 0.04 (–0.02, 0.10) 49 0.06 ± 0.17 0.06 (–0.07, 0.18)
 Week 24 (LOCF) 107 0.60 ± 0.19 0.57 (0.47, 0.71) 52 0.63 ± 0.23 0.63 (0.45, 0.81)
 Change (LOCF)b 107 0.05 ± 0.12 0.04 (–0.03, 0.10) 52 0.06 ± 0.17 0.06 (–0.06, 0.18)
LS Mean Difference −0.02 (0.02)
95% CI −0.06 to 0.03
  1. aCalculated as the weekly average
  2. bChange from baseline to Week 24
  3. LS least square, Q1 quartile 1, Q3 quartile 3, SD standard deviation