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Table 2 Daily insulin doses for the modified intention-to-treat analysis population with last observation carried forward for missing observations at Week 24

From: A randomised, open-labelstudy of insulin glargine or neutral protamine Hagedorn insulin in Chinese paediatric patients with type 1 diabetes mellitus

 

Insulin glargine

NPH insulin

 

n

Mean ± SD

Median

n

Mean ± SD

Median

   

(Q1, Q3)

  

(Q1, Q3)

Mean daily total insulin, units/kg/day ± SDa

 Baseline

107

0.84 ± 0.23

0.82 (0.67, 1.00)

53

0.87 ± 0.29

0.82 (0.70, 1.05)

 Week 24

106

0.91 ± 0.25

0.91 (0.73, 1.04)

50

1.08 ± 0.32

1.11 (0.86, 1.28)

 Changeb

106

0.08 ± 0.16

0.07 (–0.02, 0.17)

50

0.19 ± 0.26

0.18 (–0.00, 0.35)

 Week 24 (LOCF)

107

0.91 ± 0.25

0.91 (0.73, 1.04)

53

1.06 ± 0.32

1.06 (0.85, 1.26)

 Change (LOCF)b

107

0.07 ± 0.16

0.07 (–0.03, 0.17)

53

0.19 ± 0.26

0.16 (–0.00, 0.35)

LS Mean Difference

−0.13 (0.03)

95% CI

−0.19 to –0.06

Mean daily basal insulin, units/kg/day ± SDa

 Baseline

107

0.29 ± 0.09

0.28 (0.23, 0.34)

53

0.31 ± 0.13

0.32 (0.23, 0.38)

 Week 24

106

0.31 ± 0.09

0.29 (0.25, 0.37)

50

0.44 ± 0.16

0.44 (0.34, 0.52)

 Changeb

106

0.03 ± 0.07

0.02 (–0.01, 0.06)

50

0.12 ± 0.14

0.11 (0.04, 0.20)

 Week 24 (LOCF)

107

0.31 ± 0.09

0.29 (0.25, 0.38)

53

0.43 ± 0.16

0.43 (0.30, 0.50)

 Change (LOCF)b

107

0.02 ± 0.07

0.02 (–0.01, 0.06)

53

0.11 ± 0.14

0.11 (0.04, 0.20)

LS Mean Difference

−0.01 (0.02)

95% CI

−0.13 to –0.06

Mean daily bolus insulin, units/kg/day ± SD

 Baseline

107

0.55 ± 0.18

0.53 (0.42, 0.68)

52

0.58 ± 0.23

0.54 (0.40, 0.73)

 Week 24

106

0.60 ± 0.19

0.58 (0.48, 0.71)

49

0.64 ± 0.23

0.63 (0.46, 0.81)

 Changeb

106

0.05 ± 0.12

0.04 (–0.02, 0.10)

49

0.06 ± 0.17

0.06 (–0.07, 0.18)

 Week 24 (LOCF)

107

0.60 ± 0.19

0.57 (0.47, 0.71)

52

0.63 ± 0.23

0.63 (0.45, 0.81)

 Change (LOCF)b

107

0.05 ± 0.12

0.04 (–0.03, 0.10)

52

0.06 ± 0.17

0.06 (–0.06, 0.18)

LS Mean Difference

−0.02 (0.02)

95% CI

−0.06 to 0.03

  1. aCalculated as the weekly average
  2. bChange from baseline to Week 24
  3. LS least square, Q1 quartile 1, Q3 quartile 3, SD standard deviation
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