| Retinopathy | Neuropathy | AER | No microvascular alterations | |||
---|---|---|---|---|---|---|---|
 | Present | Absent | Present | Absent | Elevated | Normal | |
Age at the onset (yrs) | 8.1 (4.3)b | 10 (5.4) | 9.9 (5)h | 9.7 (5.2) | 9.9 (5.1)n | 9.8 (5.3) | 9.9(5.4) |
p = 0.001 | p = 0.655 | p = 0.821 |  | ||||
Age at study entry (yrs) | 20.7 (3.8)c | 14.5 (6) | 20.6 (4.2)i | 14.2 (5.9) | (4.2)o | 14.2 (5.9) | 14 (6) |
p = 0.0001 | p = 0.0001 | p = 0.0001 |  | ||||
Duration (yrs) | 12.6 (4.8)d | 4.5 (4.4) | 10.7 (5)j | 4.5 (4.5) | 10.7 (5)p | 4.5 (4.5) | 4.1 (4.2) |
p = 0.0001 | p = 0.0001 | p = 0.0001 |  | ||||
HbA1c (%) | 10 (2.3)e | 8.6 (2.2) | 9.3 (2.3)k | 8.7 (2.2) | 9.3 (2.3)q | 8.7 (2.2) | 8.5 (2.2) |
p = 0.0001 | p = 0.005 | p = 0.001 |  | ||||
Insulin dose (U/kg/d) | 0.91 (0.3)f | 0.78 (0.3) | 0.86 (0.3)l | 0.78 (0.3) | 0.86 (0.3)r | 0.78 (0.3) | 0.74 (0.4) |
p = 0.0001 | p = 0.01 | p = 0.044 |  | ||||
All negative antibodies (%)a | 12.5g | 7 | 9m | 7.2 | 9s | 7.2 | 7.2 |
p = 0.046 | p = 0.637 | p = 0.456 |  | ||||
GAD65 Ab levels (U/ml) | 6.5 (18.6) | 11.6 (28.9) | 11.4 (29.5) | 11.1 (28.2) | 8.3 (18.9) | 11.4 (28.9) | 11.6 (29.3) |
p = 0.092 | p = 0.913 | p = 0.307 |  | ||||
IA-2 Ab levels (U/ml) | 1.6 (3.3) t | 5.8 (10.7) | 2.5 (5.7)w | 5.7 (10.6) | 5.4 (13.8) | 5.5 (10) | 5.9 (10.4) |
p = 0.0001 | p = 0.003 | p = 0.975 |  | ||||
IAAs levels (U/ml) | 7.2 (10.2) x | 11.4 (15.3) | 9 (15.7) | 11.3 (14.9) | 7.2 (11.1) y | 11.4 (15.2) | 11.8 (15.3) |
p = 0.007 | p = 0.145 | p = 0.008 |  |