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Table 4 Clinical characteristics and autoimmunity status according to presence of diabetic microvascular complications

From: The course of diabetes in children, adolescents and young adults: does the autoimmunity status matter?

 

Retinopathy

Neuropathy

AER

No microvascular alterations

 

Present

Absent

Present

Absent

Elevated

Normal

Age at the onset (yrs)

8.1 (4.3)b

10 (5.4)

9.9 (5)h

9.7 (5.2)

9.9 (5.1)n

9.8 (5.3)

9.9(5.4)

p = 0.001

p = 0.655

p = 0.821

 

Age at study entry (yrs)

20.7 (3.8)c

14.5 (6)

20.6 (4.2)i

14.2 (5.9)

(4.2)o

14.2 (5.9)

14 (6)

p = 0.0001

p = 0.0001

p = 0.0001

 

Duration (yrs)

12.6 (4.8)d

4.5 (4.4)

10.7 (5)j

4.5 (4.5)

10.7 (5)p

4.5 (4.5)

4.1 (4.2)

p = 0.0001

p = 0.0001

p = 0.0001

 

HbA1c (%)

10 (2.3)e

8.6 (2.2)

9.3 (2.3)k

8.7 (2.2)

9.3 (2.3)q

8.7 (2.2)

8.5 (2.2)

p = 0.0001

p = 0.005

p = 0.001

 

Insulin dose (U/kg/d)

0.91 (0.3)f

0.78 (0.3)

0.86 (0.3)l

0.78 (0.3)

0.86 (0.3)r

0.78 (0.3)

0.74 (0.4)

p = 0.0001

p = 0.01

p = 0.044

 

All negative antibodies (%)a

12.5g

7

9m

7.2

9s

7.2

7.2

p = 0.046

p = 0.637

p = 0.456

 

GAD65 Ab levels (U/ml)

6.5 (18.6)

11.6 (28.9)

11.4 (29.5)

11.1 (28.2)

8.3 (18.9)

11.4 (28.9)

11.6 (29.3)

p = 0.092

p = 0.913

p = 0.307

 

IA-2 Ab levels (U/ml)

1.6 (3.3) t

5.8 (10.7)

2.5 (5.7)w

5.7 (10.6)

5.4 (13.8)

5.5 (10)

5.9 (10.4)

p = 0.0001

p = 0.003

p = 0.975

 

IAAs levels (U/ml)

7.2 (10.2) x

11.4 (15.3)

9 (15.7)

11.3 (14.9)

7.2 (11.1) y

11.4 (15.2)

11.8 (15.3)

p = 0.007

p = 0.145

p = 0.008

 
  1. All parameters are presented as mean (±SD) values unless otherwise stated
  2. yrs years, HbA1c glycosylated hemoglobin, AER albumin excretion rate, Ab antibody, GAD65 antibodies against glutamic acid decarboxylase antigen 65 kD, IA-2 antibodies against protein tyrosine phosphatase, IAAs insulin antibodies
  3. a-comparisons between groups adjusted for age at the onset of diabetes, duration and HbA1c
  4. P values comparing the group with microvascular complication with the groups without microvascular alterations: b 0.002, c 0.0001, d 0.0001, e 0.0001, f 0.001, g 0.066, h 0.889, i 0.0001, j 0.0001, k 0.001, l 0.005, m 0.527, n 0.886, o 0.0001, p 0.0001, q 0.0001, r 0.032, s 0.394, t 0.001, w 0.006, x 0.004, y 0.003