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Table 3 Comparison of metabolism related parameters between groups divided by cutoff values of TSH based on different method (using Joinpoint regression, ROC curve and conventional accepted value respectively)

From: Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort

Derivation of cutoff values

Group

No

Age (mean(SD))

BMI 24

Hyper- TC

Hyper-LDL-c

Hyper-TG

Hyper- FPG

FS9

Joinpoint regression

TSH < 2.9

2284

35.7 (9.1)

37 %

22 %

23 %

14 %

7 %

20 %

TSH2.9

572

36.9 (9.5)

35 %

27 %

27 %

18 %

8 %

23 %

P

 

0.009

0.49

0.021*

0.07

0.030*

0.46

0.18

ROC curve

TSH < 2.6

2138

35.7 (9.1)

37 %

22 %

23 %

14 %

7 %

20 %

TSH2.6

718

36.8 (9.5)

36 %

28 %

27 %

17 %

8 %

23 %

P

 

0.008

0.44

<0.001*

0.007*

0.024*

0.21

0.034*

Conventional accepted

TSH < 4.5

2714

35.9 (9.1)

37 %

23 %

24 %

15 %

7 %

20 %

TSH4.5

142

37.7 (10.2)

38 %

26 %

26 %

20 %

9 %

31 %

P

 

0.046

0.77

0.008*

0.50

0.09

0.39

0.003*

  1. Values are means(SD) or probability. Comparison between any two groups by unpaired t-test, or Pearson Chi-square test*. Data in bold are statistically significant
  2. FS Framingham score, LDL-c low-density lipoprotein cholesterol, TG triglyceride, FPG fasting plasma glucose