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Table 3 Comparison of metabolism related parameters between groups divided by cutoff values of TSH based on different method (using Joinpoint regression, ROC curve and conventional accepted value respectively)

From: Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort

Derivation of cutoff values Group No Age (mean(SD)) BMI ≧24 Hyper- TC Hyper-LDL-c Hyper-TG Hyper- FPG FS≧9
Joinpoint regression TSH < 2.9 2284 35.7 (9.1) 37 % 22 % 23 % 14 % 7 % 20 %
TSH≧2.9 572 36.9 (9.5) 35 % 27 % 27 % 18 % 8 % 23 %
P   0.009 0.49 0.021* 0.07 0.030* 0.46 0.18
ROC curve TSH < 2.6 2138 35.7 (9.1) 37 % 22 % 23 % 14 % 7 % 20 %
TSH≧2.6 718 36.8 (9.5) 36 % 28 % 27 % 17 % 8 % 23 %
P   0.008 0.44 <0.001* 0.007* 0.024* 0.21 0.034*
Conventional accepted TSH < 4.5 2714 35.9 (9.1) 37 % 23 % 24 % 15 % 7 % 20 %
TSH≧4.5 142 37.7 (10.2) 38 % 26 % 26 % 20 % 9 % 31 %
P   0.046 0.77 0.008* 0.50 0.09 0.39 0.003*
  1. Values are means(SD) or probability. Comparison between any two groups by unpaired t-test, or Pearson Chi-square test*. Data in bold are statistically significant
  2. FS Framingham score, LDL-c low-density lipoprotein cholesterol, TG triglyceride, FPG fasting plasma glucose
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BMC Endocrine Disorders

ISSN: 1472-6823

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