Skip to main content

Table 3 Cox regression models for the prediction of sex- and- age-adjusted CHD mortality and incident diabetes by 1SD of body mass index adjusted also for mediators, by gender

From: Gender-modulated risk of coronary heart disease, diabetes and coronary mortality among Turks for three major risk factors, and residual adiposity risk

 

Total

Men

Women

HR (95 % CI)

p

HR (95 % CI)

p

HR (95 % CI)

p

CHD mortality

146/2158

 

86/1015

 

60/1143

 

 Body mass index, 5 kg/m2

1.12 (1.10–1.14)

<0.001

1.11 (1.09–1.13)

0.001

1.14 (1.11–1.17)

<0,001

 Adj. Systolic BP

1.14 (0.95–1.37)

0.16

0.96 (0.72–1.28)

0.81

1.31 (1.03–1.66)

0,025

 Adj. total cholesterol

1.23 (1.05–1.45)

0.010

1.05 (0.81–1.37)

0.70

1.14 (1.11–1.17)

<0,001

 Adj. fasting glucose

1.22 (1.03–1.44)

0.021

1.04 (0.80–1.36)

0.76

1.38 (1.12–1.72)

0,003

 Adj. SBP & T Chol.

1.11 (0.93–1.34)

0.25

0.94 (0.71–1.26)

0.70

1.27 (0.99–1.62)

0,051

 Adj. SBP & FPG

1.12 (0.93–1.35)

0.21

0.93 (0.70–1.24)

0.63

1.30 (1.03–1.64)

0,025

 Adj. T Chol & FPG

1.19 (1.00–1.41)

0.050

1.11 (0.78–1.33)

0.90

1.34 (1.07–1.67)

0,008

 Adjusted for all 3 factors

1.10 (0.91–1.32)

0.31

0.91 (0.68–1.22)

0.55

1.26 (1.00–1.60)

0,050

Incident diabetes

284/2136

 

146/1014

 

138/1122

 

 Body mass index, 5 kg/m2

1.73 (1.54–1.93)

<0.001

2.11 (1.75–2.54)

0.001

1.56 (1.35–1.79)

<0,001

 Adj. Systolic BP

1.71 (1.52–1.93)

<0.001

2.13 (1.73–2.63)

0.001

1.54 (1.32–1.79)

<0,001

 Adj. total cholesterol

1.71 (1.53–1.91)

0.001

2.06 (1.70–2.49)

0.001

1.56 (1.35–1.79

0,001

 Adj. fasting glucose

1.71 (1.52–1.91)

0.001

2.10 (1.73–2.55)

0.001

1.55 (1.34–1.78

0,001

 Adj. SBP & T Chol.

1.70 (1.50–1.92)

0.001

2.09 (1.69–2.58)

0.001

1.53 (1.32–1.79)

0,001

 Adj. SBP & FPG

1.68 (1.49–1.90)

<0.001

2.09 (1.69–2.58)

0.001

1.52 (1.31–1.77)

<0,001

 Adj. T Chol & FPG

1.69 (1.51–1.90)

0.001

2.03 (1.67–2.48)

0.001

1.55 (1.34–1.78)

0,001

 Adjusted for all 3 factorsa

1.67 (1.48–1.89)

<0.001

2.05 (1.65–2.54)

0.001

1.52 (1.31–1.77)

<0,001

  1. Female sex was protected against diabetes at HR 0.58 (0.45; 0.75)
  2. 1 SD considered here for: systolic BP 25 mmHg, total cholesterol 40 mg/dl, glucose 25 mg/dl
  3. aGlucose was the only other significant determinant of diabetes
  4. Numbers in bold denote significant values