From: Familial early puberty: presentation and inheritance pattern in 139 families
PP (n = 25) | AP (n = 13) | Total (n = 38) | ||||
---|---|---|---|---|---|---|
n | m ± SD | n | m ± SD | n | m ± SD | |
Age at onset, years | 25 | 8.8 ± 0.6 | 12 | 10.7 ± 0.5 | 37 | 9.5 ± 1.1 |
Age at evaluation, years | 25 | 9.8 ± 1 | 13 | 11.4 ± 1.3 | 38 | 10.3 ± 1.3 |
Height, SDS | 25 | 2.2 ± 1.6 | 12 | 0.1 ± 1.3 | 37 | 1.6 ± 1.8 |
BMI, SDS | 24 | 1.2 ± 1 | 12 | 0.2 ± 1 | 36 | 0.9 ± 1.1 |
BA advance, years | 24 | 1.4 ± 1.2 | 10 | 0.3 ± 1.1 | 34 | 1.1 ± 1.3 |
Tanner pubic hair | 24 | 3 ± 1 | 11 | 2.8 ± 1.2 | 35 | 3 ± 1 |
Testicular volume, mm | 21 | 36.4 ± 9.3 | 10 | 39.8 ± 7 | 31 | 38 ± 8.6 |
Age at M mothers, years | 23 | 11.3 ± 1.5 | 13 | 11.4 ± 1.5 | 36 | 11.4 ± 1.5 |
LH peak, IU/L | 22 | 14.7 ± 10.5 | 10 | 15.9 ± 5.2 | 32 | 15.1 ± 9.1 |
FSH peak, IU/L | 22 | 5.4 ± 5.3 | 10 | 4.8 ± 5.6 | 32 | 5.2 ± 5.3 |
LH/FSH peak ratio | 22 | 3.4 ± 2.7 | 10 | 6.1 ± 4.4 | 32 | 4.2 ± 3.5 |
Testosterone, ng/mL | 25 | 1.8 ± 2.7 | 12 | 1.1 ± 1.1 | 37 | 1.6 ± 2.3 |
GnRH analog treatment | 25 | 2 | 13 | 2 | 38 | 4 (10 %) |