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Table 2 Univariate and multiple linear regression analyses (n = 77) to assess the impact of the following covariables on SAF: age; diabetes duration; gender; current HbA1c (current value, and HbA1c-above-target/ HbA1c-within-target); and historical HbA1c (historical value, and HbA1c-above-target/ HbA1c-within-target)

From: Increased skin autofluorescence of children and adolescents with type 1 diabetes despite a well-controlled HbA1c: results from a cohort study

 

Beta coefficient

95 % CI

P-value

Adjusted R2

Univariate analysis

 Age (years)

0.047

0.026, 0.067

<0.001

0.207

 Duration of diabetes (years)

0.025

0.013, 0.038

<0.001

0.172

 Sex (male/female)

0.047

−0.056, 0.150

0.366

−0.002

 Current HbA1c (%)

0.056

0.019, 0.092

0.003

0.097

 Historical HbA1c (%) (n = 73)

0.057

0.003, 0.111

0.040

0.045

 Current HbA1c: HbA1c-above-target vs. Hba1c-within-target

0.034

−0.104, 0.172

0.628

−0.010

 Historical HbA1c: HbA1c-above-target vs. Hba1c-within-target (n = 73)

0.028

−0.092, 0.147

0.645

−0.011

Multiple linear regression analysis

Model 1 (n = 77)

   

0.265

  Age (years)

0.040

0.019, 0.061

<0.001

 

  Diabetes duration 4 to <10 years vs. ≤ 4 years

0.065

−0.044, 0.172

0.239

  Diabetes duration ≥10 years vs. ≤ 4 years

0.187

0.053, 0.320

0.007

Model 2 (n = 73)

   

0.235

  Age (years)

0.043

0.022, 0.065

<0.001

 

  Diabetes duration 4 to <10 years vs. ≤ 4 years

0.056

−0.064, 0.175

0.356

  Diabetes duration ≥10 years vs. ≤ 4 years

0.179

0.030, 0.328

0.019

  Current HbA1c: HbA1c-above-target vs. Hba1c-within-target

0.012

−0.138, 0.162

0.872

  Historical HbA1c: HbA1c-above-target vs. Hba1c-within-target

−0.048

−0.172, 0.077

0.446

  1. HbA1c-above-target: > 7.5 %/59 mmol/mol; Hba1c-within-target HbA1c: ≤ 7.5 %/59 mmol/mol