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Table 4 Main results for different scenarios ordered by life expectancy assumptions (means per patient)

From: Cost effectiveness and value of information analyses of islet cell transplantation in the management of ‘unstable’ type 1 diabetes mellitus

Scenario Cost Benefit ICER
Index Description Standard care Islet cell transplantation Cost difference Standard care Islet cell transplantation Benefit difference  
  Structural scenarios with difference in LE = 12 years a
1 5 % discount rate (base case) $56,560 $347,377 $290,816 9.59 11.52 1.94 $150,006
2 3.5 % discount rate $67,363 $369,647 $302,284 11.14 13.51 2.37 $127,278
3 3 % discount rate $71,695 $378,532 $306,837 11.76 14.31 2.56 $120,008
4 Undiscounted $109,303 $455,743 $346,440 17.08 21.36 4.28 $80,917
5 5 % discount rate; life years $56,560 $347,377 $290,816 14.08 15.12 1.05 $278,188
6 Undiscounted; life years $109,303 $455,743 $346,440 25.30 28.63 3.33 $104,177
7 Undiscounted; double disutilities $109,303 $455,743 $346,440 14.29 19.86 5.56 $62,254
8 Generic Imm.b $56,560 $273,741 $217,180 9.59 11.52 1.94 $112,023
9 Generic Imm.b; 1 % discount rate $94,062 $320,265 $226,203 14.93 18.48 3.55 $63,668
10 Generic Imm.b; each transplantation costs $20,000 less $56,560 $231,843 $175,283 9.59 11.52 1.94 $90,412
11 Increased costs in IIT (110 %) and DRC (125 %) states $66,426 $352,527 $286,100 9.59 11.52 1.94 $147,573
12 As row above but undiscounted and doubled disutilities in IIT and DRC states $129,361 $468,444 $339,083 14.29 19.86 5.56 $60,932
  Structural scenarios with difference in LE = 10 years a
13 5 % discount rate $60,863 $349,993 $289,130 9.93 11.73 1.80 $160,394
14 3 % discount rate $78,527 $382,868 $304,341 12.30 14.66 2.36 $128,877
15 Undiscounted; life years $123,916 $465,610 $341,694 27.20 29.94 2.74 $124,804
  Structural scenarios with difference in LE = 14 years a
16 5 % discount rate $51,693 $344,471 $292,778 9.22 11.31 2.09 $140,095
17 3 % discount rate $64,301 $373,931 $309,630 11.20 13.96 2.77 $111,867
18 Undiscounted; life years $94,621 $446,014 $351,393 23.43 27.36 3.93 $89,402
  1. All scenarios used the base case assumptions with the described structural deviations. Benefit measure is QALY unless noted otherwise. All result numbers are rounded and including sampling variation. Superscripts: a The assumed difference in life expectancy (LE) caused by hypoglycemia unawareness compared to the non-diabetes population used in the model. b This scenario assumes generic version immunosuppression