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Table 4 Main results for different scenarios ordered by life expectancy assumptions (means per patient)

From: Cost effectiveness and value of information analyses of islet cell transplantation in the management of ‘unstable’ type 1 diabetes mellitus

Scenario

Cost

Benefit

ICER

Index

Description

Standard care

Islet cell transplantation

Cost difference

Standard care

Islet cell transplantation

Benefit difference

 
 

Structural scenarios with difference in LE = 12 years a

1

5 % discount rate (base case)

$56,560

$347,377

$290,816

9.59

11.52

1.94

$150,006

2

3.5 % discount rate

$67,363

$369,647

$302,284

11.14

13.51

2.37

$127,278

3

3 % discount rate

$71,695

$378,532

$306,837

11.76

14.31

2.56

$120,008

4

Undiscounted

$109,303

$455,743

$346,440

17.08

21.36

4.28

$80,917

5

5 % discount rate; life years

$56,560

$347,377

$290,816

14.08

15.12

1.05

$278,188

6

Undiscounted; life years

$109,303

$455,743

$346,440

25.30

28.63

3.33

$104,177

7

Undiscounted; double disutilities

$109,303

$455,743

$346,440

14.29

19.86

5.56

$62,254

8

Generic Imm.b

$56,560

$273,741

$217,180

9.59

11.52

1.94

$112,023

9

Generic Imm.b; 1 % discount rate

$94,062

$320,265

$226,203

14.93

18.48

3.55

$63,668

10

Generic Imm.b; each transplantation costs $20,000 less

$56,560

$231,843

$175,283

9.59

11.52

1.94

$90,412

11

Increased costs in IIT (110 %) and DRC (125 %) states

$66,426

$352,527

$286,100

9.59

11.52

1.94

$147,573

12

As row above but undiscounted and doubled disutilities in IIT and DRC states

$129,361

$468,444

$339,083

14.29

19.86

5.56

$60,932

 

Structural scenarios with difference in LE = 10 years a

13

5 % discount rate

$60,863

$349,993

$289,130

9.93

11.73

1.80

$160,394

14

3 % discount rate

$78,527

$382,868

$304,341

12.30

14.66

2.36

$128,877

15

Undiscounted; life years

$123,916

$465,610

$341,694

27.20

29.94

2.74

$124,804

 

Structural scenarios with difference in LE = 14 years a

16

5 % discount rate

$51,693

$344,471

$292,778

9.22

11.31

2.09

$140,095

17

3 % discount rate

$64,301

$373,931

$309,630

11.20

13.96

2.77

$111,867

18

Undiscounted; life years

$94,621

$446,014

$351,393

23.43

27.36

3.93

$89,402

  1. All scenarios used the base case assumptions with the described structural deviations. Benefit measure is QALY unless noted otherwise. All result numbers are rounded and including sampling variation. Superscripts: a The assumed difference in life expectancy (LE) caused by hypoglycemia unawareness compared to the non-diabetes population used in the model. b This scenario assumes generic version immunosuppression
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BMC Endocrine Disorders

ISSN: 1472-6823

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