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Table 2 Utilitiy weights and disutility parameters (annual)

From: Cost effectiveness and value of information analyses of islet cell transplantation in the management of ‘unstable’ type 1 diabetes mellitus

Condition Weight Disutility (Decrement) SD RSD Distribution Hyperparameters Sourcea
Type 1 diabetes (T1DM) no complicationsb 0.81 0.01      [38, 39]
Full graft function no complicationsc 0.82 [Base value] 0.041 5 % Beta α = 70.56 T1DM no complications plus “no-injection bonus” minus immunosuppression disutility (assumptions)
β = 15.48
Partial graft function no complications 0.81 0.01 (0.01) 0.002 20 % Gamma α = 25.00 Same as T1DM but with different uncertainty
β = 0.0004
Hypoglycemia unawareness (intensive insulin therapy) 0.71 0.11 (0.10) 0.020 20 % Gamma α = 25.00 Assumption based on [44]
β = 0.004
Diabetes-related complications (additional to hypoglycemia unawareness)
Amputation 0.60 0.22      Assumption based on [39, 47]
Blindness or severe vision loss 0.63 0.19      Assumption based on [39, 47]
Nephropathy 0.47 0.35      Assumption based on [47]
Heart failure 0.55 0.27      Assumption based on [45]
Stroke 0.49 0.33      Assumptions based on [46]
Myocardial infarction 0.49 0.33
Angina pectoris 0.62 0.20
Aggregated diabetes-related complications 0.57 0.25 (0.14) 0.042 30 % Gamma α = 11.11 Weighted mean of 7 complications above with frequency data from [33] minus 0.03 to account for multiple complication cases
β = 0.0126
One-time disutilities (per occurrence)
Initial immunosuppressive or other complications X-0.05 0.05 0.010 20 % Gamma α = 25.00 Assumption based on [2] and expert opinion
β = 0.002
Subsequent major immunosuppressive complications X-0.10 0.10 0.025 25 % Gamma α = 16.00 Assumption based on [2] and expert opinion
β = 0.00625
  1. Bold values were directly used as model inputs and for calculating mean, standard deviation (SD) and relative standard deviation (RSD; i.e., SD as percentage of the mean). Other values are rounded and were incorporated into bold values. Superscripts: a Source relates to mean values. SD values were the authors’ estimations due to lack of data. b All other conditions also included type 1 diabetes and where applicable hypoglycemia unawareness. c From this value the corresponding disutility increments of the other conditions were subtracted