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Table 2 Utilitiy weights and disutility parameters (annual)

From: Cost effectiveness and value of information analyses of islet cell transplantation in the management of ‘unstable’ type 1 diabetes mellitus

Condition

Weight

Disutility (Decrement)

SD

RSD

Distribution

Hyperparameters

Sourcea

Type 1 diabetes (T1DM) no complicationsb

0.81

0.01

    

[38, 39]

Full graft function no complicationsc

0.82

[Base value]

0.041

5 %

Beta

α = 70.56

T1DM no complications plus “no-injection bonus” minus immunosuppression disutility (assumptions)

β = 15.48

Partial graft function no complications

0.81

0.01 (0.01)

0.002

20 %

Gamma

α = 25.00

Same as T1DM but with different uncertainty

β = 0.0004

Hypoglycemia unawareness (intensive insulin therapy)

0.71

0.11 (0.10)

0.020

20 %

Gamma

α = 25.00

Assumption based on [44]

β = 0.004

Diabetes-related complications (additional to hypoglycemia unawareness)

Amputation

0.60

0.22

    

Assumption based on [39, 47]

Blindness or severe vision loss

0.63

0.19

    

Assumption based on [39, 47]

Nephropathy

0.47

0.35

    

Assumption based on [47]

Heart failure

0.55

0.27

    

Assumption based on [45]

Stroke

0.49

0.33

    

Assumptions based on [46]

Myocardial infarction

0.49

0.33

Angina pectoris

0.62

0.20

Aggregated diabetes-related complications

0.57

0.25 (0.14)

0.042

30 %

Gamma

α = 11.11

Weighted mean of 7 complications above with frequency data from [33] minus 0.03 to account for multiple complication cases

β = 0.0126

One-time disutilities (per occurrence)

Initial immunosuppressive or other complications

X-0.05

0.05

0.010

20 %

Gamma

α = 25.00

Assumption based on [2] and expert opinion

β = 0.002

Subsequent major immunosuppressive complications

X-0.10

0.10

0.025

25 %

Gamma

α = 16.00

Assumption based on [2] and expert opinion

β = 0.00625

  1. Bold values were directly used as model inputs and for calculating mean, standard deviation (SD) and relative standard deviation (RSD; i.e., SD as percentage of the mean). Other values are rounded and were incorporated into bold values. Superscripts: a Source relates to mean values. SD values were the authors’ estimations due to lack of data. b All other conditions also included type 1 diabetes and where applicable hypoglycemia unawareness. c From this value the corresponding disutility increments of the other conditions were subtracted