Type 1 diabetes (T1DM) no complications^{b}

0.81

0.01
    
[38, 39]

Full graft function no complications^{c}

0.82

[Base value]

0.041

5 %

Beta

α = 70.56

T1DM no complications plus “noinjection bonus” minus immunosuppression disutility (assumptions)

β = 15.48

Partial graft function no complications

0.81

0.01 (0.01)

0.002

20 %

Gamma

α = 25.00

Same as T1DM but with different uncertainty

β = 0.0004

Hypoglycemia unawareness (intensive insulin therapy)

0.71

0.11 (0.10)

0.020

20 %

Gamma

α = 25.00

Assumption based on [44]

β = 0.004

Diabetesrelated complications (additional to hypoglycemia unawareness)

Amputation

0.60

0.22
    
Assumption based on [39, 47]

Blindness or severe vision loss

0.63

0.19
    
Assumption based on [39, 47]

Nephropathy

0.47

0.35
    
Assumption based on [47]

Heart failure

0.55

0.27
    
Assumption based on [45]

Stroke

0.49

0.33
    
Assumptions based on [46]

Myocardial infarction

0.49

0.33

Angina pectoris

0.62

0.20

Aggregated diabetesrelated complications

0.57

0.25 (0.14)

0.042

30 %

Gamma

α = 11.11

Weighted mean of 7 complications above with frequency data from [33] minus 0.03 to account for multiple complication cases

β = 0.0126

Onetime disutilities (per occurrence)

Initial immunosuppressive or other complications

X0.05

0.05

0.010

20 %

Gamma

α = 25.00

Assumption based on [2] and expert opinion

β = 0.002

Subsequent major immunosuppressive complications

X0.10

0.10

0.025

25 %

Gamma

α = 16.00

Assumption based on [2] and expert opinion

β = 0.00625
