The efficacy and safety of probiotics intervention in preventing conversion of impaired glucose tolerance to diabetes: study protocol for a randomized, double-blinded, placebo controlled trial of the Probiotics Prevention Diabetes Programme (PPDP)

Table 1 Visit study and efficacy variables for Probiotics Prevention Diabetes Programme (PPDP)

Visit number	1	2	3	4	5	6	7	8	9	10	11	12	13
Study month	0	2 m	4 m	6 m	8 m	10 m	12 m	14 m	16 m	18 m	20 m	22 m	24 m
Newly diagnosed diabetes(n)	×			×			×			×			×
OGTT + IRT(0 min,30 min,2 h)^a	×			×			×			×			×
Total cholesterol	×			×			×			×			×
Triglyceride	×			×			×			×			×
High-density lipoprotein	×			×			×			×			×
Low-density lipoprotein	×			×			×			×			×
Body weight	×	×	×	×	×	×	×	×	×	×	×	×	×
Systolic blood pressure	×	×	×	×	×	×	×	×	×	×	×	×	×
Diastolic blood pressure	×	×	×	×	×	×	×	×	×	×	×	×	×
Waist circumference	×	×	×	×	×	×	×	×	×	×	×	×	×
Hip circumference	×			×			×			×			×
Abundance of bacteria	×			×			×			×			×
LPS	×			×			×			×			×
GLP-1	×			×			×			×			×

^aOGTT, oral glucose tolerance test; IRT, insulin release test; LPS, lipopolysaccharides

ISSN: 1472-6823