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Table 4 Categorical weight loss in SEISMIC and persistence during the LTE study

From: Sustained weight loss in patients treated with mifepristone for Cushing’s syndrome: a follow-up analysis of the SEISMIC study and long-term extension

Categorical weight loss in SEISMIC

Time point in LTE study

Weight loss persistencea, n (%)

≥5 % weight loss (n = 18)b

Month 6

14 (82.4)

Final visitc

15 (83.3)

≥10 % weight loss (n = 10)b

Month 6

8 (80)

Final visitc

8 (80)

  1. aPersistence is defined as maintenance of the weight loss threshold in SEISMIC to LTE assessment time points. bOne subject was excluded from this analysis because the only post-baseline weight was assessed on the day of death, which occurred in the hospital in relation to a serious adverse event deemed not related to study drug by the investigator. cFinal visit is defined as the last post-entry observation collected during the LTE study
  2. LTE long-term extension