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Table 3 Persistence of weight loss in SEISMIC and the LTE

From: Sustained weight loss in patients treated with mifepristone for Cushing’s syndrome: a follow-up analysis of the SEISMIC study and long-term extension

 

SEISMIC

LTE

Variable

Baseline (n = 29)

Week 24 (n = 29)

Month 6 (n = 27)

Month 18 (n = 25)

Final visit (n = 29)

Weight, kg

     

 Mean ± SD

105.4 ± 34.3

97.2 ± 30.8

95.2 ± 32.2

96.6 ± 34.7

95.1 ± 32.9

 Change weight

—

−8.2 ± 9.3

−10.5 ± 12.3

−11.4 ± 18.7

−10.3 ± 16.3

 % Change in weight

—

−7.5 ± 7.1

−9.7 ± 9.7

−10.0 ± 14.4

−9.3 ± 13.4

BMI, kg/m2

     

 Mean ± SD

37.7 ± 11.7

34.7 ± 10.0

34.3 ± 9.7

34.0 ± 9.7

33.7 ± 9.9

BMI category, n (%)

     

  ≥ 30

21 (72.4)

17 (58.6)

16 (59.3)

16 (64.0)

18 (62.1)

  ≥ 40

9 (31.0)

7 (24.1)

6 (22.2)

4 (16.0)

6 (20.7)

  1. Final visit is defined as the last post-entry observation collected during the LTE study
  2. BMI body mass index; LTE long-term extension
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BMC Endocrine Disorders

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