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Table 1 Annual mean (95 % CI) number of SHEs in patients with T1 and T2 DM

From: Drug-related risk of severe hypoglycaemia in observational studies: a systematic review and meta-analysis

Therapy

Average number of SHEs per patient per year

Probability of ≥1 SHE for a patient annually

T1

Insulin pump

0.168 (0.123–0.237)

11.38 % (8.09 %–16.03 %)

Basal-bolus (basal insulin analogue)

0.472 (0.252–1.055)

21.37 % (11.30 %–42.97 %)

Basal-bolus (basal human insulin)

1.084 (0.530–2.900)

33.77 % (17.93 %–67.53 %)

T2

BOT analogue

0.113 (0.050–0.324)

5.55 % (2.32 %–15.62 %)

BOT human

0.173 (0.072–0.600)

7.95 % (3.18 %–26.35 %)

Basal-bolus (basal insulin analogue)

0.080 (0.027–0.456)

4.78 % (1.21 %–27.04 %)

Basal-bolus (basal human insulin)

0.554 (0.157–7.534)

31.40 % (7.44 %–99.64 %)

Pre-mix insulin analogue

0.092 (0.052–0.186)

6.23 % (3.41 %–12.49 %)

Pre-mix human insulin

0.299 (0.137–0.868)

12.43 % (5.87 %–31.85 %)

Sulfonylureas

0.045 (0.023–0.115)

3.57 % (1.91 %–7.56 %)

  1. BOT Basal therapy combined with oral antidiabetic medication, SHE Severe hypoglycaemia event, T1, T2 DM Type 1, Type 2 diabetes mellitus