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Table 3 Geometric mean (95 % confidence interval) leukocyte telomere lengtha by diabetes status, diabetes control, and diabetes duration, 1999–2002

From: Leukocyte telomere length and diabetes status, duration, and control: the 1999–2002 National Health and Nutrition Examination Survey

 

Unadjusted

Age, race-ethnicity, and sex adjusted

Multivariable adjustedb

Diabetes status

p < 0.01

p = 0.68

p = 0.11

 Normal

1.045 (1.010–1.082)

1.012 (0.979–1.046)

1.000 (0.967–1.034)

 Prediabetes

0.970 (0.937–1.006)

1.010 (0.974–1.048)

1.009 (0.970–1.050)

 Diabetes

0.946 (0.918–0.974)

1.020 (0.989–1.053)

1.032 (0.996–1.069)

Duration among those with diabetes

p = 0.44

p = 0.90

p = 0.57

 Undiagnosed

0.970 (0.937–1.006)

0.965 (0.932–0.999)

0.957 (0.921–0.994)

 Duration 0–2 years

0.977 (0.916–1.041)

0.966 (0.901–1.035)

0.983 (0.917–1.055)

 Duration 3–5 years

0.969 (0.920–1.022)

0.984 (0.938–1.032)

0.971 (0.909–1.037)

 Duration 6–10 years

0.950 (0.889–1.015)

0.974 (0.918–1.033)

0.974 (0.904–1.050)

 Duration ≥11 years

0.927 (0.884–0.972)

0.982 (0.938–1.028)

0.989 (0.940–1.041)

Control among diagnosed diabetes (7 %)

p = 0.43

p = 0.65

p = 0.43

  A1c <7 % (53 mmol/mol)

0.943 (0.909–0.978)

0.954 (0.918–0.992)

0.955 (0.911–1.001)

  A1c ≥7 % (53 mmol/mol)

0.956 (0.920–0.993)

0.947 (0.913–0.982)

0.939 (0.904–0.976)

Control among diagnosed diabetes (8 %)

p = 0.80

p = 0.12

p = 0.20

  A1c <8 % (64 mmol/mol)

0.948 (0.915–0.983)

0.961 (0.927–0.997)

0.957 (0.918–0.999)

  A1c ≥8 % (64 mmol/mol)

0.953 (0.912–0.997)

0.930 (0.891–0.971)

0.926 (0.882–0.973)

  1. aTelomere length was measured relative to standard reference DNA and presented as a ratio (T/S ratio)
  2. bMultivariable model adjusted for age, race-ethnicity, sex, education, income, smoking, pack years smoked, alcohol consumption, body mass index, and C-reactive protein