NGT-NGT | NGT-IGT/T2D | P-value | |
---|---|---|---|
N | 100 | 14 | |
Follow-up time (years) | 5.3 ± 2.4 | 6.9 ± 2.2 | 0.028 |
Age (years) | 39.5 ± 6.8 | 43.6 ± 5.3 | 0.039 |
Sex (% male) | 46 (46 %) | 4 (28,5 %) | n.s. |
Weight (kg) | 77.2 ± 13.1 | 74.7 ± 11.6 | n.s. |
BMI (kg/m2) | 24.9 ± 3.3 | 25.4 ± 3.3 | n.s. |
Waist (cm) | 88.1 ± 10.3 | 89.1 ± 10.1 | n.s. |
Waist/hip circumference ratio | 0.86 ± 0.09 | 0.87 ± 0.08 | n.s. |
Systolic blood pressure (mmHg) | 117 ± 10 | 121 ± 9 | n.s. |
Diastolic blood pressure (mmHg) | 75 ± 9 | 74 ± 6 | n.s. |
Fat percent (%) | 24.7 ± 8.1 | 28.4 ± 7.3 | n.s. |
High heredity for T2D | 56 (59 %) | 11 (79 %) | <0.001 |
High physical activity | 36 (38 %) | 7 (50 %) | n.s. |
Currently smoking | 11 (11 %) | 2 (14 %) | n.s. |
Fasting plasma glucose (mmol/L) | 4.8 ± 0.4 | 4.9 ± 0.5 | n.s. |
Fasting plasma insulin (pmol/L) | 45.7 ± 28.9 | 44.7 ± 13.4 | n.s. |
OGTT 2 h plasma glucose (mmol/L) | 5.5 ± 1.1 | 6.4 ± 0.9 | 0.007 |
HbA1c (mmol/mol) | 32.4 ± 2.2 | 33.6 ± 2.8 | 0.067 |
M-value (GIR/lbm/min 30 min) | 13.5 ± 3.8 | 11.7 ± 3.3 | n.s. |
M/I (GIR/lbm/min/ pmol/L) | 0.02 ± 0.01 | 0.02 ± 0.01 | n.s. |
IVGTT AIR (pmol/L x min) | 3295 ± 2060 | 3483 ± 2500 | n.s. |
IVGTT LIR (pmol/L x min) | 7354 ± 4089 | 8999 ± 4868 | n.s. |
HOMA-IR (mmol x mU/L2) | 9.6 ± 6.5 | 9.6 ± 3.4 | n.s. |
Serum cholesterol (mmol/l) | 4.8 ± 0.9 | 5.2 ± 0.9 | n.s. |
Serum HDL (mmol/L) | 1.6 ± 0.4 | 1.7 ± 0.4 | n.s. |
Serum triglycerides (mmol/L) | 1.0 ± 0.5 | 1.0 ± 0.3 | n.s. |
Serum LDL (mmol/L) | 2.7 ± 0.7 | 3.0 ± 0.8 | n.s. |
Serum ALT μkat/L) | 0.42 ± 0.25 | 0.41 ± 0.21 | n.s. |
Serum CRP (mg/L) | 1.16 ± 2.27 | 1.01 ± 1.15 | n.s. |
Serum creatinine (μmol/L) | 87 ± 15 | 97 ± 24 | 0.046 |
Adipocyte cell size (μm) | 92.2 ± 12.4 | 98.2 ± 16.0 | n.s. |
Serum adiponectin (μg/mL) | 9.2 ± 4.7 | 8.8 ± 4.0 | n.s |
Il-6 (ng/mL) | 43.4 ± 22.6 | 51.4 ± 17.5 | n.s. |