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Table 3 Baseline characteristics of subjects with NGT at baseline, according to glycemic control status at follow-up

From: Metabolic predictors of impaired glucose tolerance and type 2 diabetes in a predisposed population – A prospective cohort study

 

NGT-NGT

NGT-IGT/T2D

P-value

N

100

14

 

Follow-up time (years)

5.3 ± 2.4

6.9 ± 2.2

0.028

Age (years)

39.5 ± 6.8

43.6 ± 5.3

0.039

Sex (% male)

46 (46 %)

4 (28,5 %)

n.s.

Weight (kg)

77.2 ± 13.1

74.7 ± 11.6

n.s.

BMI (kg/m2)

24.9 ± 3.3

25.4 ± 3.3

n.s.

Waist (cm)

88.1 ± 10.3

89.1 ± 10.1

n.s.

Waist/hip circumference ratio

0.86 ± 0.09

0.87 ± 0.08

n.s.

Systolic blood pressure (mmHg)

117 ± 10

121 ± 9

n.s.

Diastolic blood pressure (mmHg)

75 ± 9

74 ± 6

n.s.

Fat percent (%)

24.7 ± 8.1

28.4 ± 7.3

n.s.

High heredity for T2D

56 (59 %)

11 (79 %)

<0.001

High physical activity

36 (38 %)

7 (50 %)

n.s.

Currently smoking

11 (11 %)

2 (14 %)

n.s.

Fasting plasma glucose (mmol/L)

4.8 ± 0.4

4.9 ± 0.5

n.s.

Fasting plasma insulin (pmol/L)

45.7 ± 28.9

44.7 ± 13.4

n.s.

OGTT 2 h plasma glucose (mmol/L)

5.5 ± 1.1

6.4 ± 0.9

0.007

HbA1c (mmol/mol)

32.4 ± 2.2

33.6 ± 2.8

0.067

M-value (GIR/lbm/min 30 min)

13.5 ± 3.8

11.7 ± 3.3

n.s.

M/I (GIR/lbm/min/ pmol/L)

0.02 ± 0.01

0.02 ± 0.01

n.s.

IVGTT AIR (pmol/L x min)

3295 ± 2060

3483 ± 2500

n.s.

IVGTT LIR (pmol/L x min)

7354 ± 4089

8999 ± 4868

n.s.

HOMA-IR (mmol x mU/L2)

9.6 ± 6.5

9.6 ± 3.4

n.s.

Serum cholesterol (mmol/l)

4.8 ± 0.9

5.2 ± 0.9

n.s.

Serum HDL (mmol/L)

1.6 ± 0.4

1.7 ± 0.4

n.s.

Serum triglycerides (mmol/L)

1.0 ± 0.5

1.0 ± 0.3

n.s.

Serum LDL (mmol/L)

2.7 ± 0.7

3.0 ± 0.8

n.s.

Serum ALT μkat/L)

0.42 ± 0.25

0.41 ± 0.21

n.s.

Serum CRP (mg/L)

1.16 ± 2.27

1.01 ± 1.15

n.s.

Serum creatinine (μmol/L)

87 ± 15

97 ± 24

0.046

Adipocyte cell size (μm)

92.2 ± 12.4

98.2 ± 16.0

n.s.

Serum adiponectin (μg/mL)

9.2 ± 4.7

8.8 ± 4.0

n.s

Il-6 (ng/mL)

43.4 ± 22.6

51.4 ± 17.5

n.s.

  1. NGT = normal glucose tolerance. IGT = impaired glucose tolerance. IL-6 = interleukin-6. Data are mean ± standard deviation. P-values have been calculated as stated in Methods. P-values below 0.1 are given numerically, otherwise stated as not significant (n.s.)