Fig. 3

Kaplan-Meier curve for cardiovascular events during 104 weeks in patients with T2DM with or without a history of cardiovascular events. Number of patients in each drug group is listed in Table 1. Numbers of those in which 104-week follow-up was completed were 629 in SU, 1305 in biguanide, 592 in α-GI, 351 in TZD, 223 in glinide, and 995 in DPP-4 inhibitor groups, respectively (Table 1). Numbers of those in which a cardiovascular event was observed were 80 in SU, 84 in biguanide, 63 in α-GI, 35 in TZD, 21 in glinide, and 87 in DPP-4 inhibitor groups, respectively (Table 3A). Statistical comparison of cardiovascular events during 104 weeks in patients with T2DM with a history of cardiovascular events is shown in the inserted small table. Hazard ratio, Cox proportional hazard model adjusted by sex, age, HbA1c value (NGSP), use or non-use of anti-hypertensive drugs, use or non-use of anti-dyslipidemia drugs. CI indicates a 95 % confidence interval. **P < 0.01