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Table 1 Tumor characteristics and MEN1variations in insulinoma patients

From: Novel MEN 1 gene findings in rare sporadic insulinoma—a case control study

ID.

Age/Sex

Tumour characteristics

MEN1 variations found

Location

Size

Nature

 M1

35/M

3

2.0 a2.0 cm

B

Q260Ra

A541T (rs2959656)d

H433H (rs 540012)d

 M2

38/M

3

4.8a5.9 cm

M

H433H (rs 540012)d

 M3

23/M

3

1.0a0.8 cm

B

H433H (rs 540012)d

D418D (rs2071313)d

 M4

34/M

3

0.8a0.9 cm

B

H433H (rs 540012)d

A541T (rs2959656)d

 M5

42/M

3

1.0 x 0.8 cm

B

H433H (rs 540012)d

D418D (rs2071313)d

 M6

35/F

2

2.0 a2.0 cm

B

Q260Ra

H433H (rs 540012)d

D418D (rs2071313)d

A541T (rs2959656)d

 M7

65/F

2

1.5a1.2 cm

B

M561Ka

H433H (rs 540012)d

D418D (rs2071313)d

A541T (rs2959656)d

Intronic rs 669976 e

 M8

50/F

2

3.0a2.0 cm

B

H433H (rs 540012)d

D418D (rs2071313)d

A541T (rs2959656)d

 M9

25/M

4

4.0a5.0 cm

B

H433H (rs 540012)d

A541T (rs2959656)d

 M10

29/F

4

1.0a0.5 cm

B

H433H (rs 540012)d

A541T (rs2959656)d

 M11

16/M

3

1.0 x 1.0 cm

B

H433H (rs 540012)d

A541T (rs2959656)d

 M12

18/F

3

2.0 x 1.0 cm

B

H433H (rs 540012)d

Intronic rs 669976 e

A541T (rs2959656)d

 M13

17/M

4.

2.0 a2.0 cm

B

Q192K a

H433H (rs 540012)d

 M14.

45/F

1

3.0a2.0 cm

B

Q261Qb

H433H (rs 540012)d

D418D (rs2071313)d

A541T (rs2959656)d

 M15.

46/M

4

1.0a1.0 cm

B

H433H (rs 540012)d

A541T (rs2959656)d

 M16.

30/M

4

1.0a1.0 cm

B

Intronic c.913-42G → Cc

H433H (rs 540012)d

D418D (rs2071313)d

 M17

41/F

4

0.85a0.65 cm

B

Intronic c.445-44G → Ac

H433H (rs 540012)d

A541T (rs2959656)d

  1. Legend: M male, F female, B benign, M malignant, 1-junction of neck and body of the pancreas, 2-uncinate process of the pancreas, 3-head of the pancreas, 4-tail of the pancreas. a - novel non synonymous exonic mutations, b- novel synonymous exonic mutation, c novel intronic variations, d -reported exonic polymorphisms, e- reported intronic polymorphisms