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Fig. 4 | BMC Endocrine Disorders

Fig. 4

From: Effects of hypoxia inducible factor-1α on apoptotic inhibition and glucocorticoid receptor downregulation by dexamethasone in AtT-20 cells

Fig. 4

Downregulation of GR by dexamethasone under hypoxia conditions was HIF-1α-dependent. Under normoxia or hypoxic incubation for 12h, mRNA and protein expression levels of HIF-1α (a,c), GR (b,c) in cells transfected with HIF-1α-siRNA compared to nontransfected cells after dexamethasone treatment (24h). (d) Quantification of (c) (*P < 0.05 vs siRNA)

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BMC Endocrine Disorders

ISSN: 1472-6823

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